ArticleThe Journal of physiology1999
Adenosine-induced presynaptic inhibition of IPSCs and EPSCs in rat hypothalamic supraoptic nucleus neurones.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 109 citations in OpenAlex.
- Selective block of adenosine ABritish journal of pharmacology · 2022Article
- Adenosine, caffeine, and sleep-wake regulation: state of the science and perspectives.Journal of sleep research · 2022Review
- The hypothalamus predates the origin of vertebrates.Science advances · 2021Article
- Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation.Journal of neuroendocrinology · 2020Review
- Effect of adenosine on short-term synaptic plasticity in mouse piriform cortex in vitro: adenosine acts as a high-pass filter.Physiological reports · 2019Article
- Sleep homeostasis and the circadian clock: Do the circadian pacemaker and the sleep homeostat influence each other's functioning?Neurobiology of sleep and circadian rhythms · 2018Review
- Adenosine Differentially Modulates Synaptic Transmission of Excitatory and Inhibitory Microcircuits in Layer 4 of Rat Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Purinergic signaling pathways in endocrine system.Autonomic neuroscience : basic & clinical · 2015Review
- Contribution of extrasynaptic N-methyl-D-aspartate and adenosine A1 receptors in the generation of dendritic glutamate-mediated plateau potentials.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.Journal of neurophysiology · 2015Article
- Purinergic signalling in endocrine organs.Purinergic signalling · 2014Review
- Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Journal of neuroendocrinology · 2013Review
- Article
- Tonic regulation of GABAergic synaptic activity on vasopressin neurones by cannabinoids.Journal of neuroendocrinology · 2012Article
- Kainate receptor-induced retrograde inhibition of glutamatergic transmission in vasopressin neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Central clock excites vasopressin neurons by waking osmosensory afferents during late sleep.Nature neuroscience · 2010Article
- Glia-dependent switch of kainate receptor presynaptic action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Feedback inhibition of action potential discharge by endogenous adenosine enhancement of the medium afterhyperpolarization.The Journal of physiology · 2009Article
- Activity-dependent release of adenosine: a critical re-evaluation of mechanism.Current neuropharmacology · 2008Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
1. The effects of adenosine on synaptic transmission in magnocellular neurosecretory cells were investigated using whole-cell patch-clamp recordings in acute rat hypothalamic slices that included the supraoptic nucleus. 2. Adenosine reversibly reduced the amplitude of evoked inhibitory (IPSCs) and excitatory (EPSCs) postsynaptic currents in a dose-dependent manner (IC50 approximately 10 microM for both types of current). 3. Depression of IPSCs and EPSCs by adenosine was reversed by the application of the A1 adenosine receptor antagonist 8-cyclopentyl-1, 3-dimethylxanthine (CPT; 10 microM). 4. When pairs of stimuli were given at short intervals, adenosine inhibitory action was always less effective on the second of the two responses than on the first, resulting in an increased paired-pulse facilitation and suggesting a presynaptic site of action. This observation was confirmed by analysis of spontaneous miniature synaptic currents whose frequency, but not amplitude or kinetics, was reversibly reduced by 100 microM adenosine. 5. CPT had no effect on synaptic responses evoked at a low frequency of stimulation (0.05-0.5 Hz), indicating the absence of tonic activation of A1 receptors under these recording conditions. However, CPT inhibited a time-dependent depression of both IPSCs and EPSCs induced during a 1 Hz train of stimuli. 6. Taken together, these results suggest that adenosine can be released within the supraoptic nucleus at a concentration sufficient to inhibit the release of GABA and glutamate via the activation of presynaptic A1 receptors. By its inhibitory feedback action on the major afferent inputs to oxytocin and vasopressin neurones, adenosine could optimally adjust electrical and secretory activities of hypothalamic magnocellular neurones.
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