Trial reportJournal of medical genetics1999
Club foot, an adverse outcome of early amniocentesis: disruption or deformation? CEMAT. Canadian Early and Mid-Trimester Amniocentesis Trial.
Trial report in Journal of medical genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical Practice Guidelines for Prenatal Aneuploidy Screening and Diagnostic Testing from Korean Society of Maternal-Fetal Medicine: (2) Invasive Diagnostic Testing for Fetal Chromosomal Abnormalities.Journal of Korean medical science · 2021Guideline
- Amniocentesis and chorionic villus sampling for prenatal diagnosis.The Cochrane database of systematic reviews · 2017Pooled it
- Amniocentesis and chorionic villus sampling for prenatal diagnosis.The Cochrane database of systematic reviews · 2003Pooled it
- Determinants for Congenital Clubfoot in Ethiopia: A Case-Control Study at Black Lion Specialized Hospital.Health science reports · 2026Article
- Article
- The Incidence of Clubfoot in the Czech Republic: A Nationwide Epidemiological Study from 2000 to 2014.Children (Basel, Switzerland) · 2023Article
- Invasive Prenatal Diagnostic Testing for Aneuploidies in Singleton Pregnancies: A Comparative Review of Major Guidelines.Medicina (Kaunas, Lithuania) · 2022Review
- Apoptotic genes expression in placenta of clubfoot-like fetus pregnant rats.International journal of clinical and experimental pathology · 2014Article
- Ponseti method compared with soft-tissue release for the management of clubfoot: A meta-analysis study.World journal of orthopedics · 2013Article
- Congenital talipes equinovarus: an epidemiological study in Sicily.Acta orthopaedica · 2012Article
- Congenital talipes equinovarus (clubfoot): a disorder of the foot but not the hand.Journal of anatomy · 2003Review
- Prenatal diagnosis for paediatricians.Paediatrics & child health · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An association between the occurrence of club foot and early amniocentesis has been reported. The largest of these randomised studies was the Canadian Early and Mid-Trimester Amniocentesis Trial. Data describing the neonatal outcome, focusing on this association, are presented. Possible mechanisms for the association and the implications for the development of club foot are discussed.
Indexed as
Identifiers
10544229PMC1734259What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.