ArticleThe Journal of experimental medicine1999
Selective expansion of cross-reactive CD8(+) memory T cells by viral variants.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 114 citations in OpenAlex.
- Trial
- Article
- Deconvoluting the T Cell Response to SARS-CoV-2: Specificity Versus Chance and Cognate Cross-Reactivity.Frontiers in immunology · 2021Article
- Tissue-resident CD8Science immunology · 2020Article
- Pre-existing heterologous T-cell immunity and neoantigen immunogenicity.Clinical & translational immunology · 2020Review
- Mouse Models of Heterologous Flavivirus Immunity: A Role for Cross-Reactive T Cells.Frontiers in immunology · 2019Review
- Article
- Guidelines for the use of flow cytometry and cell sorting in immunological studies.European journal of immunology · 2017Article
- A heat-inactivated H7N3 vaccine induces cross-reactive cellular immunity in HLA-A2.1 transgenic mice.Virology journal · 2016Article
- Increased Immune Response Variability during Simultaneous Viral Coinfection Leads to Unpredictability in CD8 T Cell Immunity and Pathogenesis.Journal of virology · 2015Article
- Cryopreservation of MHC multimers: Recommendations for quality assurance in detection of antigen specific T cells.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2015Article
- Vaccination and heterologous immunity: educating the immune system.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2015Review
- Inflammatory responses to infection: the Dutch contribution.Immunology letters · 2014Article
- The two faces of heterologous immunity: protection or immunopathology.Journal of leukocyte biology · 2014Review
- Cross-protective immune responses elicited by live attenuated influenza vaccines.Yonsei medical journal · 2013Review
- Cross-reactivity of T cells and its role in the immune system.Critical reviews in immunology · 2012Review
- Multiple distinct forms of CD8+ T cell cross-reactivity and specificities revealed after 2009 H1N1 influenza A virus infection in mice.PloS one · 2012Article
- The polyclonal CD8 T cell response to influenza M158-66 generates a fully connected network of cross-reactive clonotypes to structurally related peptides: a paradigm for memory repertoire coverage of novel epitopes or escape mutants.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Heterologous immunity: immunopathology, autoimmunity and protection during viral infections.Autoimmunity · 2011Review
- T cell recognition of weak ligands: roles of signaling, receptor number, and affinity.Immunologic research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of memory T cells during the immune response against random antigenic variants has not been resolved. Here, we show by simultaneous staining with two tetrameric major histocompatibility complex (MHC)-peptide molecules, that the polyclonal CD8(+) T cell response against a series of natural variants of the influenza A nucleoprotein epitope is completely dominated by infrequent cross-reactive T cells that expand from an original memory population. Based on both biochemical and functional criteria, these cross-reactive cytotoxic T cells productively recognize both the parental and the mutant epitope in vitro and in vivo. These results provide direct evidence that the repertoire of antigen-specific T cells used during an infection critically depends on prior antigen encounters, and indicate that polyclonal memory T cell populations can provide protection against a range of antigenic variants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.