ArticleThe Journal of experimental medicine1999
CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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Who cites it
109 citing papers in PubMed.
- Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver.iScience · 2025Article
- Lipids regulate peripheral serotonin release via gut CD1d.Immunity · 2023Article
- T-betCell metabolism · 2022Article
- Gut Microbiota-Derived Unconventional T Cell Ligands: Contribution to Host Immune Modulation.ImmunoHorizons · 2022Article
- Article
- Ocular Inflammation and Treatment Emergent Adverse Events in Retinal Gene Therapy.International ophthalmology clinics · 2021Article
- Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment.Journal for immunotherapy of cancer · 2021Article
- CD1d deficiency limits tolerogenic properties of peritoneal macrophages.BMB reports · 2021Article
- Animal models of high-risk corneal transplantation: A comprehensive review.Experimental eye research · 2020Review
- Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates.Nature communications · 2020Article
- SLAM-SAP-Fyn: Old Players with New Roles in iNKT Cell Development and Function.International journal of molecular sciences · 2019Review
- Thymic regulatory T cells arise via two distinct developmental programs.Nature immunology · 2019Article
- Natural killer T cells mediate inflammation in the bile ducts.Mucosal immunology · 2018Article
- Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells.Science (New York, N.Y.) · 2018Article
- Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection.Frontiers in immunology · 2018Article
- A non-canonical function of Ezh2 preserves immune homeostasis.EMBO reports · 2017Article
- Cellular and Molecular Mechanisms of Anterior Chamber-Associated Immune Deviation (ACAID): What We Have Learned from Knockout Mice.Frontiers in immunology · 2017Review
- Review
- Lysophosphatidylcholine plays critical role in allergic airway disease manifestation.Scientific reports · 2016Article
- Natural Killer T Cells Contribute to Neutrophil Recruitment and Ocular Tissue Damage in a Model of Intraocular Tumor Rejection.Investigative ophthalmology & visual science · 2016Article
49 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
Systemic tolerance can be elicited by introducing antigen into an immune-privileged site, such as the eye, or directly into the blood. Both routes of immunization result in a selective deficiency of systemic delayed type hypersensitivity. Although the experimental animal model of anterior chamber-associated immune deviation (ACAID) occurs in most mouse strains, ACAID cannot be induced in several mutant mouse strains that are coincidentally deficient in natural killer T (NKT) cells. Therefore, this model for immune-privileged site-mediated tolerance provided us with an excellent format for studying the role of NKT cells in the development of tolerance. The following data show that CD1-reactive NKT cells are required for the development of systemic tolerance induced via the eye as follows: (a) CD1 knockout mice were unable to develop ACAID unless they were reconstituted with NKT cells together with CD1(+) antigen-presenting cells; (b) specific antibody depletion of NKT cells in vivo abrogated the development of ACAID; and (c) anti-CD1 monoclonal antibody treatment of wild-type mice prevented ACAID development. Significantly, CD1-reactive NKT cells were not required for intravenously induced systemic tolerance, thereby establishing that different mechanisms mediate development of tolerance to antigens inoculated by these routes. A critical role for NKT cells in the development of systemic tolerance associated with an immune-privileged site suggests a mechanism involving NKT cells in self-tolerance and their defects in autoimmunity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.