ArticleGenes & development1999
Tagging chromatin with retrotransposons: target specificity of the Saccharomyces Ty5 retrotransposon changes with the chromosomal localization of Sir3p and Sir4p.
Article in Genes & development, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Progresses of transposon research inSynthetic and systems biotechnology · 2026Review
- Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective.Mobile DNA · 2020Review
- Single-Nucleotide-Specific Targeting of the Tf1 Retrotransposon Promoted by the DNA-Binding Protein Sap1 of Schizosaccharomyces pombe.Genetics · 2015Article
- The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans.Virulence · 2014Review
- BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.Molecular therapy. Nucleic acids · 2014Article
- Access to DNA establishes a secondary target site bias for the yeast retrotransposon Ty5.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Functional characteristics of a highly specific integrase encoded by an LTR-retrotransposon.PloS one · 2008Article
- Retrotransposon target site selection by imitation of a cellular protein.Molecular and cellular biology · 2008Article
- Calling cards for DNA-binding proteins.Genome research · 2007Article
- Insertion of group II intron retroelements after intrinsic transcriptional terminators.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Retroviral DNA integration: viral and cellular determinants of target-site selection.PLoS pathogens · 2006Article
- Hos2 and Set3 promote integration of Ty1 retrotransposons at tRNA genes in Saccharomyces cerevisiae.Genetics · 2006Article
- DNA damage and L1 retrotransposition.Journal of biomedicine & biotechnology · 2006Article
- Sir-dependent downregulation of various aging processes.Molecular genetics and genomics : MGG · 2005Article
- Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genome.Journal of virology · 2005Article
- Article
- Article
- Local definition of Ty1 target preference by long terminal repeats and clustered tRNA genes.Genome research · 2004Article
- CEN plasmid segregation is destabilized by tethered determinants of Ty 5 integration specificity: a role for double-strand breaks in CEN antagonism.Chromosoma · 2003Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Retrotransposon and retroviral insertions are not randomly distributed on chromosomes, suggesting that retroelements actively select integration sites. This is the case for the yeast Ty5 retrotransposons, which preferentially integrate into domains of silent chromatin at the HM loci and telomeres. Here we demonstrate that loss of Sir3p or Sir4p-components of silent chromatin-causes a greater than ninefold decrease in Ty5 targeting to the HM loci and largely randomizes chromosomal integration patterns. Strains with a deletion of SIR4 also display an approximately 10-fold increase in cDNA recombination, which is due both to the expression a- and alpha-mating-type information and the loss of Sir4p. It is known that in old yeast cells or in strains carrying the sir4-42 allele, the Sir complex relocalizes to the rDNA. About 26% of Ty5 insertions occur within the rDNA in sir4-42 strains compared with 3% in wild type. Ty5, therefore, is sensitive to changes in chromatin, indicating that retrotransposons may be useful for dissecting chromatin dynamics that occur during developmental programs such as aging.
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