ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Serotonin depletion does not prevent intrinsic sensitization in the leech.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Circuit-constrained molecular neuroethology in the medicinal leech Hirudo verbana.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Endocannabinoid-mediated potentiation of nonnociceptive synapses contributes to behavioral sensitization.Journal of neurophysiology · 2018Article
- Modulation of defensive reflex conditioning in snails by serotonin.Frontiers in behavioral neuroscience · 2015Article
- Protection from premature habituation requires functional mushroom bodies in Drosophila.Learning & memory (Cold Spring Harbor, N.Y.) · 2007Article
- Postactivation inhibition of spontaneously active neurosecretory neurons in the medicinal leech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2007Article
- Comparative studies of the effects of chlorpromazine and 5,6-dihydroxytryptamine on locomotion, defensive reactions in the snail Helix lucorum, and command neuron excitability in long-term sensitization.Neuroscience and behavioral physiology · 2006Article
- Nonassociative learning as gated neural integrator and differentiator in stimulus-response pathways.Behavioral and brain functions : BBF · 2006Article
- Plasticity of the acoustic startle reflex in currently abstinent ecstasy (MDMA) users.Psychopharmacology · 2004Article
- Non-associative learning and serotonin induce similar bi-directional changes in excitability of a neuron critical for learning in the medicinal leech.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Intrinsic sensitization is a form of behavioral facilitation that is distinct from the extrinsic sensitization normally studied. To examine whether intrinsic and extrinsic sensitization are mediated by different physiological processes, the effects of 5,7-dihydroxytryptamine-induced serotonin (5-HT) depletion on intrinsic sensitization of the leech whole-body shortening response were observed. Previous experiments have shown that 5-HT depletion disrupts dishabituation and extrinsic sensitization of this behavior in the leech. Intrinsic sensitization was observed in preparations from both control and 5-HT-depleted animals, indicating that this form of behavioral facilitation was not affected by 5-HT depletion. The differences in the effects of 5-HT depletion on intrinsic versus extrinsic sensitization suggest that there are distinct neurophysiological processes mediating these two forms of behavioral facilitation. In addition, 5-HT depletion appeared to disrupt a putative extrinsic form of habituation of the shortening reflex. These data support the hypothesis that both intrinsic and extrinsic processes of neuromodulation mediate habituation and sensitization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.