ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Inhibition of the endothelial isoform of nitric oxide synthase impairs long-term memory formation in the chick.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 39 citations in OpenAlex.
- Ellagic acid prevents dementia through modulation of PI3-kinase-endothelial nitric oxide synthase signalling in streptozotocin-treated rats.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.American journal of physiology. Heart and circulatory physiology · 2015Article
- 7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice.Drug target insights · 2015Article
- Effects of 7-NI and ODQ on memory in the passive avoidance, novel object recognition, and social transmission of food preference tests in mice.Medical science monitor basic research · 2014Article
- Involvement of nitric oxide in learning & memory processes.The Indian journal of medical research · 2011Review
- Effects of Selective iNOS Inhibitor on Spatial Memory in Recovered and Non-Recovered Ketamine Induced Anesthesia.Iranian journal of pharmaceutical research : IJPR · 2011Article
- Effects of Selective iNOS Inhibitor on Spatial Memory in Recovered and Non-recovered Ketamine Induced-anesthesia in Wistar Rats.Iranian journal of pharmaceutical research : IJPR · 2010Article
- Nitric oxide is necessary for multiple memory processes after learning that a food is inedible in aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Hemispheric dissociation of the involvement of NOS isoforms in memory for discriminated avoidance in the chick.Learning & memory (Cold Spring Harbor, N.Y.)Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies with general inhibitors of nitric oxide synthase have yielded variable and contradictory results with respect to their effects on memory. This may have been due to differential effects of blocking the various isoforms of this enzyme. We show that day-old chicks trained on a single-trial passive-avoidance task suffered significant memory loss from approximately 40 min post-training following post-training intracranial administration of a potent inhibitor of eNOS. Administration of a specific nNOS or iNOS inhibitor at the same time had no effect on retention, although a role for either of these isoforms when administered at a different time after learning has yet to be fully investigated. The onset of memory loss following eNOS inhibition is the same as observed following general NOS inhibition, which suggests that amnestic effects observed in previous studies using nonspecific inhibitors may be attributable to blocking the function of eNOS. The findings indicate that eNOS may play a role in memory formation for this task, which is at least distinct from any role that may be played by nNOS.
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