Evidence map›Paper›PMID 10540698›Full record

SynthesisCanadian family physician Medecin de famille canadien1999

Clinical effectiveness of pneumococcal vaccine. Meta-analysis.

B G Hutchison, A D Oxman, H S Shannon, S Lloyd, C A Altmayer, K Thomas

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC
In one paragraph

Synthesis in Canadian family physician Medecin de famille canadien, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 6 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Vaccines for preventing pneumococcal infection in adults.The Cochrane database of systematic reviews · 2013
    Pooled it
  2. Randomisation to protect against selection bias in healthcare trials.The Cochrane database of systematic reviews · 2011
    Pooled it
  3. Efficacy of pneumococcal vaccination in adults: a meta-analysis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2009
    Pooled it
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  9. Cluster randomised controlled trial of an educational outreach visit to improve influenza and pneumococcal immunisation rates in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2002
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

B G HutchisonDepartment of Family Medicine, McMaster University in Hamilton, Ont. hutchb@fhs.mcmaster.ca
A D Oxman
H S Shannon
S Lloyd
C A Altmayer
K Thomas
McMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the clinical effectiveness of pneumococcal vaccine. DATA SOURCES: Computerized searches of MEDLINE, EMBASE, and SCISEARCH databases were performed, reference lists of retrieved articles were reviewed, and first authors of published studies were contacted. STUDY SELECTION: Studies of use of pneumococcal vaccines in adults were included if the study design was a randomized or quasi-randomized controlled trial and at least one of the following clinical outcomes was reported: vaccine-type systemic pneumococcal infection, systemic pneumococcal infection, vaccine-type pneumococcal pneumonia, pneumococcal pneumonia, non-vaccine-type pneumococcal pneumonia. SYNTHESIS: Study quality was assessed and descriptive information concerning the study populations, interventions, and outcome measurements was extracted for 13 trials involving more than 65,000 patients. Estimates of vaccine efficacy, based on a meta-analysis of randomized and quasi-randomized trials, were determined for clinical outcomes.

conclusionsVaccination with pneumococcal polysaccharide vaccine can be expected to reduce the risk of systemic infection due to pneumococcal types included in the vaccine by 83% and systemic infection due to all pneumococci by 73%. We found no evidence that the vaccine was less efficacious for the elderly, institutionalized people, or those with chronic disease.

Indexed as

VaccinationAdolescentAdultAge FactorsBacterial VaccinesChronic DiseaseHumansMiddle AgedPneumococcal InfectionsStreptococcus pneumoniaeBacterial Vaccines

Identifiers

PMID10540698
PMCPMC2328641
OpenAlexW1486000670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.