Evidence map›Paper›PMID 10536645›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences1999

Life stress, mood disturbance, and elevated interleukin-6 in healthy older women.

S K Lutgendorf, L Garand, K C Buckwalter, T T Reimer, S Y Hong, D M Lubaroff

Registry-linked trialAbstract readClinical TrialControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04137913 (Project CHROMA), which is not on this map. Cited by 80 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04137913 nacompletednot on this mapstarted 2019, after this paper: background citation

Project CHROMA (Cognitive Health Research on Musical Arts)

TypeinterventionalSponsorWilliam Marsh Rice UniversityRan2019 to 2023Enrolled81ConditionsCognitive Impairment, CreativityArmsMusical arts intervention
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Health-and disease-related biomarkers in aging research.Research in gerontological nursing · 2009
    Pooled it
  4. Trial
  5. Trial
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  8. Trial
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Support-Giving Is Associated With Lower Systemic Inflammation.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023
    Article
  16. Review
  17. Microglia as Central Protagonists in the Chronic Stress Response.Neurology(R) neuroimmunology & neuroinflammation · 2022
    Review
  18. Article
  19. Review
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

S K LutgendorfDepartment of Psychology, University of Iowa, USA. susan-lutgendorf@uiowa.edu
L Garand
K C Buckwalter
T T Reimer
S Y Hong
D M Lubaroff

Funding

Translation CoreP30NR003979 · NINR · UNIVERSITY OF IOWA · PI MAAS, MERIDEAN L · 1994 to 2008
$3.8M
USE OF AN IN VIVO MODEL SYSTEM TO INVESTIGATE NIDDMZ01AG000214 · NIA · NATIONAL INSTITUTE ON AGING · PI EGAN, JOSEPHINE M · 1991 to 2008
$693k
INTERDISCIPLINARY RESEARCH TRAINING PROGRAM ON AGINGT32AG000214 · NIA · UNIVERSITY OF IOWA · PI WALLACE, ROBERT BRUCE · 1991 to 2000
$164k
PSYCHOIMMUNOLOGICAL OUTCOMES OF A CAREGIVER INTERVENTIONF31NR007114 · NINR · UNIVERSITY OF IOWA · PI GARAND, LINDA J · 1998 to 1998
–
Intramural NIH HHS Z01 AG000214NIAAA NIH HHS T32 AAG00214NIA NIH HHS T32 AG000214NINR NIH HHS F31 NR007114NINR NIH HHS P30 NR003979NINR NIH HHS P30NR03979NINR NIH HHS R01NR034340452
6 · The paper itself

Abstract

backgroundAlthough adverse effects of severe chronic stress on immunocompetence and physical well-being in older adults have been reported, the immune response to less severe life stress among healthy older adults, particularly among women, is not well understood. Interleukin-6 (IL-6) has been considered a good overall indicator of immune functioning in older adults because of its contribution to the pathogenesis of several age-related conditions such as osteoporosis. Regulation of IL-6 is impaired in elderly adults, and levels of IL-6 increase with stress and depression. This research cross-sectionally examined levels of IL-6 in three groups of healthy older women with varying levels of life stress and mood disturbance and a healthy group of young women.

methodsSubjects included 18 caregivers of Alzheimer's patients, 17 older women assessed one month before relocation of their residence, 15 nonmoving and noncaregiving older women, and 20 younger women. Subjects completed the Profile of Mood States (POMS) and had early morning blood draws.

resultsAlzheimer's caregivers reported significantly greater distress than women of all other groups. IL-6 levels in caregivers were significantly higher than those of all other women. The older women had significantly higher IL-6 than young controls, but there were no significant differences in IL-6 between movers and older controls. Among all women, greater depression and distress were related to higher levels of IL-6.

conclusionsThese findings suggest that in older women, chronic stressors are associated with significant elevations in IL-6 over and above the elevations associated with normal aging, but that moderate stressors may not be related to appreciable elevations in IL-6.

Indexed as

ImmunocompetenceAgedAged, 80 and overAnalysis of VarianceCaregiversCross-Sectional StudiesFemaleHumansInterleukin-6Middle AgedMood DisordersPsychometricsReference ValuesStress, PhysiologicalInterleukin-6

Identifiers

PMID10536645
PMCPMC6642656

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.