ArticleProceedings of the National Academy of Sciences of the United States of America1999
Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons.Cell reports · 2025Article
- Early Polytherapy for Probably Benzodiazepine Refractory Naïve Status Epilepticus (Stage 1 Plus).Neurology international · 2025Review
- γ1 GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- GABA system as the cause and effect in early development.Neuroscience and biobehavioral reviews · 2024Review
- GABAIUPHAR/BPS guide to pharmacology CITE · 2021Article
- GABAJournal, genetic engineering & biotechnology · 2021Review
- Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAFrontiers in cellular neuroscience · 2017Article
- Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.Neuropharmacology · 2015Article
- Synaptic GABAA receptor clustering without the γ2 subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Review
- Type A GABA-receptor-dependent synaptic transmission sculpts dendritic arbor structure in Xenopus tadpoles in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors.Molecular and cellular neurosciences · 2008Article
- Excitation Control: Balancing PSD-95 Function at the Synapse.Frontiers in molecular neuroscience · 2008Article
- GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- GABA(A) receptors: structure and function in the basal ganglia.Progress in brain research · 2007Review
- GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Distinct gamma2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Preferential accumulation of GABAA receptor gamma 2L, not gamma 2S, cytoplasmic loops at rat spinal cord inhibitory synapses.The Journal of physiology · 2004Article
- The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- GABAergic innervation organizes synaptic and extrasynaptic GABAA receptor clustering in cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic localization of gamma-aminobutyric acid type A (GABA(A)) receptors is a prerequisite for synaptic inhibitory function, but the mechanism by which different receptor subtypes are localized to postsynaptic sites is poorly understood. The gamma2 subunit and the postsynaptic clustering protein gephyrin are required for synaptic localization and function of major GABA(A) receptor subtypes. We now show that transgenic overexpression of the gamma3 subunit in gamma2 subunit-deficient mice restores benzodiazepine binding sites, benzodiazepine-modulated whole cell currents, and postsynaptic miniature currents, suggesting the formation of functional, postsynaptic receptors. Moreover, the gamma3 subunit can substitute for gamma2 in the formation of GABA(A) receptors that are synaptically clustered and colocalized with gephyrin in vivo. These clusters were formed even in brain regions devoid of endogenous gamma3 subunit, indicating that the factors present for clustering of gamma2 subunit-containing receptors are sufficient to cluster gamma3 subunit-containing receptors. The GABA(A) receptor and gephyrin-clustering properties of the ectopic gamma3 subunit were also observed for the endogenous gamma3 subunit, but only in the absence of the gamma2 subunit, suggesting that the gamma3 subunit is at a competitive disadvantage with the gamma2 subunit for clustering of postsynaptic GABA(A) receptors in wild-type mice.
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