ArticleProceedings of the National Academy of Sciences of the United States of America1999
Activation changes the spectrum but not the diversity of genes expressed by T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 221 citations in OpenAlex.
- mScience advances · 2026Article
- Multi-omics integration analysis identifies INPP4B as a T-cell-specific activation suppressor.Clinical and translational medicine · 2025Article
- Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients.Frontiers in immunology · 2025Article
- Dissecting the Immune System through Gene Regulation.Advances in experimental medicine and biology · 2024Article
- A strategy to protect off-the-shelf cell therapy products using virus-specific T-cells engineered to eliminate alloreactive T-cells.Journal of translational medicine · 2019Article
- Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation.Cell reports · 2017Article
- Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs.Journal of visualized experiments : JoVE · 2016Article
- Loss of T-cell quiescence by targeting Slfn2 prevents the development and progression of T-ALL.Oncotarget · 2016Article
- The novel chicken interleukin 26 protein is overexpressed in T cells and induces proinflammatory cytokines.Veterinary research · 2016Article
- T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Metabolic regulation of T cell differentiation and function.Molecular immunology · 2015Review
- Genetic evidence that intratumoral T-cell proliferation and activation are associated with recurrence and survival in patients with resected colorectal liver metastases.Cancer immunology research · 2015Article
- Cluster Analysis of Tumor Suppressor Genes in Canine Leukocytes Identifies Activation State.Bioinformatics and biology insights · 2015Article
- T-cell activation and early gene response in dogs.PloS one · 2015Article
- Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.PloS one · 2014Article
- Transcriptomic response of porcine PBMCs to vaccination with tetanus toxoid as a model antigen.PloS one · 2013Article
- A microRNA network regulates proliferative timing and extracellular matrix synthesis during cellular quiescence in fibroblasts.Genome biology · 2012Article
- The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.Immunity · 2011Article
- The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function.Nature immunology · 2011Article
- Potential of soluble CD26 as a serum marker for colorectal cancer detection.World journal of clinical oncology · 2011Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
During activation T cells are thought to change their patterns of gene expression dramatically. To find out whether this is true for T cells activated in animals, the patterns of genes expressed in resting T cells and T cells 8 and 48 hr after activation were examined by using Affymetrix gene arrays. Gene arrays gave accurate comparisons of gene expression in the different cell types because the expression of genes known to vary during activation changed as expected. Of the approximately 6,300 genes assessed by the arrays, about one-third were expressed to appreciable extents in any of the T cells tested. Thus, resting T cells express a surprisingly large diversity of genes. The patterns of gene expression changed considerably within 8 hr of T cell activation but returned to a disposition more like that of resting T cells within 48 hr of exposure to antigen. Not unexpectedly, the activated T cells expressed genes associated with cell division at higher levels than resting T cells. The resting T cells expressed a number of cytokine receptor genes and some genes thought to suppress cell division, suggesting that the state of resting T cells is not a passive failure to respond to extant external stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.