ArticleProceedings of the National Academy of Sciences of the United States of America1999
Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 211 citations in OpenAlex.
- Mammography and ultrasound effective features in differentiating basal-like and normal-like subtypes of triple negative breast cancer.Oncotarget · 2017Article
- Physical activity induced protection against breast cancer risk associated with delayed parity.Physiology & behavior · 2017Article
- Randomness and preserved patterns in cancer network.Scientific reports · 2014Article
- Quantitative Analysis of the Human Milk Whey Proteome Reveals Developing Milk and Mammary-Gland Functions across the First Year of Lactation.Proteomes · 2013Article
- Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts.Molecular & cellular proteomics : MCP · 2012Article
- Breast cancer proteomics: a review for clinicians.Journal of cancer research and clinical oncology · 2011Review
- Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines.Breast cancer research : BCR · 2010Article
- The differential expression of aqueous soluble proteins in breast normal and cancerous tissues in relation to stage and grade of patients.Journal of biomedicine & biotechnology · 2010Article
- Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues.BMC genomics · 2009Article
- Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1.Breast cancer research : BCR · 2008Article
- Moving forward in colorectal cancer research, what proteomics has to tell.World journal of gastroenterology · 2007Review
- Basal-like breast cancer and the BRCA1 phenotype.Oncogene · 2006Review
- Differential expression of a C-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated Ser262 that localizes to the Golgi compartment.The Biochemical journal · 2006Article
- Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.Breast cancer research : BCR · 2006Article
- Bcl-x(L)-mediated changes in metabolic pathways of breast cancer cells: from survival in the blood stream to organ-specific metastasis.The American journal of pathology · 2005Article
- Article
- Do myoepithelial cells hold the key for breast tumor progression?Journal of mammary gland biology and neoplasia · 2005Review
- Myoepithelial cells: pathology, cell separation and markers of myoepithelial differentiation.Journal of mammary gland biology and neoplasia · 2005Review
- Cystic duct dilatations and proliferative epithelial lesions in mouse mammary glands upon keratin 5 promoter-driven overexpression of cyclooxygenase-2.The American journal of pathology · 2005Article
- Myoepithelial cells: good fences make good neighbors.Breast cancer research : BCR · 2005Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal human luminal and myoepithelial breast cells separately purified from a set of 10 reduction mammoplasties by using a double antibody magnetic affinity cell sorting and Dynabead immunomagnetic technique were used in two-dimensional gel proteome studies. A total of 43,302 proteins were detected across the 20 samples, and a master image for each cell type comprising a total of 1,738 unique proteins was derived. Differential analysis identified 170 proteins that were elevated 2-fold or more between the two breast cell types, and 51 of these were annotated by tandem mass spectrometry. Muscle-specific enzyme isoforms and contractile intermediate filaments including tropomyosin and smooth muscle (SM22) alpha protein were detected in the myoepithelial cells, and a large number of cytokeratin subclasses and isoforms characteristic of luminal cells were detected in this cell type. A further 134 nondifferentially regulated proteins were also annotated from the two breast cell types, making this the most extensive study to date of the protein expression map of the normal human breast and the basis for future studies of purified breast cancer cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.