ArticleJournal of muscle research and cell motility1999
Opposite changes in myosin heavy chain composition of human masseter and biceps brachii muscles during aging.
Article in Journal of muscle research and cell motility, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Effects of age on human skeletal muscle: a systematic review and meta-analysis of myosin heavy chain isoform protein expression, fiber size, and distribution.American journal of physiology. Cell physiology · 2024Pooled it
- Differences in the force/endurance relationship between young and older men.European journal of applied physiology · 2005Trial
- Review
- Optimizing Confocal Imaging Protocols for Muscle Fiber Typing in the Mouse Masseter Muscle.Bio-protocol · 2025Article
- A Biomechanical Simulation of Forearm Flexion Using the Finite Element Approach.Bioengineering (Basel, Switzerland) · 2023Article
- Progressive Protrusive Tongue Exercise Does Not Alter Aging Effects in Retrusive Tongue Muscles.Frontiers in physiology · 2021Article
- Aging induced loss of complexity and dedifferentiation: consequences for coordination dynamics within and between brain, muscular and behavioral levels.Frontiers in aging neuroscience · 2014Article
- Effects of aging and sex on voluntary activation and peak relaxation rate of human elbow flexors studied with motor cortical stimulation.Age (Dordrecht, Netherlands) · 2013Article
- Effects of aging on thyroarytenoid muscle regeneration.The Laryngoscope · 2012Article
- Remarkable heterogeneity in myosin heavy-chain composition of the human young masseter compared with young biceps brachii.Histochemistry and cell biology · 2012Article
- Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle.PloS one · 2012Article
- Fiber type and myosin heavy chain compositions of adult pretarsal orbicularis oculi muscle.Journal of molecular histology · 2007Article
- Developmental and functional considerations of masseter muscle partitioning.Archives of oral biology · 2007Review
- Human single masseter muscle fibers contain unique combinations of myosin and myosin binding protein C isoforms.Journal of muscle research and cell motility · 2002Article
- Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres.Archives of oral biology · 2001Article
- Maximum shortening velocity and myosin heavy-chain isoform expression in human masseter muscle fibers.Journal of dental research · 2001Article
- Post-translational phosphorylation of the slow/beta myosin heavy chain isoform in adult rabbit masseter muscle.Journal of muscle research and cell motility · 2001Article
- Dynamic nature of fibre-type specific expression of myosin heavy chain transcripts in 14 different human skeletal muscles.Journal of muscle research and cell motility · 2001Article
- Characterisation of human soft palate muscles with respect to fibre types, myosins and capillary supply.Journal of anatomy · 2000Article
- Myosin heavy chain composition of the human lateral pterygoid and digastric muscles in young adults and elderly.Journal of muscle research and cell motility · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The myosin heavy chain (MyHC) content in functionally different parts of the human masseter muscle of six elderly and five young adult subjects (mean age 74 and 22 years, respectively) was determined, using gel electrophoresis. The MyHC composition of the old masseter was also studied by enzyme- and immunohistochemical methods and compared with previous data for young adults. For comparison, the biceps brachii muscle of the same subjects was also analysed. The old masseter contained smaller amounts of slow and larger amounts of fast and fetal MyHCs. These differences were region-dependent and were more pronounced in the superficial portion. There was also a larger proportion of "hybrid" fibres, containing two to four MyHC isoforms (42%), compared with the young adult masseter (23%). No such differences were observed between old and young biceps. In contrast to the masseter, the old biceps contained more slow MyHC and less fast MyHC. This investigation demonstrates that the aging process in human skeletal muscle is accompanied by a modification in the muscle phenotype which is both muscle and region specific; a transformation towards a fast and fetal phenotype concomitant with an increased number of fibres with a mixture of different MyHC isoforms in the masseter; and an opposite shift towards a slower phenotype in the biceps brachii. The results might reflect differences between jaw and limb muscles in genetic programs and adaptive responses to changed functional demands following aging.
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