ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
The neural cell adhesion molecules L1 and NCAM-180 act in different steps of neurite outgrowth.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 56 citations in OpenAlex.
- The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth.Cell calcium · 2024Article
- Review
- Mechanosensitive axon outgrowth mediated by L1-laminin clutch interface.Biophysical journal · 2021Article
- Optical manipulation of molecular function by chromophore-assisted light inactivation.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2021Review
- Neuronal adhesion and synapse organization in recovery after brain injury.Future neurology · 2013Article
- CD146 deletion in the nervous system impairs appetite, locomotor activity and spatial learning in mice.PloS one · 2013Article
- Chromophore-assisted laser inactivation in neural development.Neuroscience bulletin · 2012Review
- Role of SDF1/CXCR4 interaction in experimental hemiplegic models with neural cell transplantation.International journal of molecular sciences · 2012Review
- Pharmacology of cell adhesion molecules of the nervous system.Current neuropharmacology · 2007Article
- Quantification of N-CAM and N-cadherin expression in axotomized and crushed rat sciatic nerve.Journal of anatomy · 2005Article
- Growth cone pathfinding: a competition between deterministic and stochastic events.BMC neuroscience · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The formation of neurocircuitry depends on the control of neurite outgrowth that, in turn, can be divided into two processes: nerve growth cone protrusion and neurite extension. It has long been known that the neural cell adhesion molecules L1 and NCAM-180 promote neurite outgrowth, but how they function in growth cones is unclear. We addressed the roles of L1 and NCAM-180 in neurite outgrowth by using microscale chromophore-assisted laser inactivation (micro-CALI) of these proteins to perturb their functions at precise times in single growth cones of embryonic chick dorsal root ganglion neurons grown in culture. Micro-CALI of L1 causes neurite retraction after a 10 min lag period but does not affect growth cone protrusion. In contrast, micro-CALI of NCAM-180 causes rapid growth cone retraction but does not affect neurite extension. The simultaneous inactivation of both these molecules resulted in both distinct effects that were segregated in time. The behavior of growth cones after these micro-CALI treatments resemble the drug-induced perturbation of microtubules for L1 and F-actin for NCAM-180. These findings suggest distinct roles in the growth cone for L1 and NCAM-180 in different steps of neurite outgrowth: L1 functions in neurite extension,whereas NCAM-180 functions in growth cone protrusion.
Indexed as
Identifiers
10531450PMC6782940W2138259221What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.