ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Neuralization of the Xenopus embryo by inhibition of p300/ CREB-binding protein function.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
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- xCITED2 Induces Neural Genes in Animal Cap Explants of Xenopus Embryos.Experimental neurobiology · 2011Article
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- foxD5 plays a critical upstream role in regulating neural ectodermal fate and the onset of neural differentiation.Developmental biology · 2009Article
- Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.The Journal of biological chemistry · 2008Article
- GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis.Developmental biology · 2007Article
- Retinoic acid-inducible G protein-coupled receptors bind to frizzled receptors and may activate non-canonical Wnt signaling.Biochemical and biophysical research communications · 2007Article
- Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.Developmental cell · 2007Article
- Xenopus laevis POU91 protein, an Oct3/4 homologue, regulates competence transitions from mesoderm to neural cell fates.The EMBO journal · 2006Article
- Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.Genes & development · 2003Article
- Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling.Molecular and cellular biology · 2001Article
- p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation.Molecular and cellular biology · 2000Article
- The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates.The EMBO journal · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
p300/ CREB-binding protein (CBP) is a transcriptional coactivator for a plethora of transcription factors and plays critical roles in signal transduction pathways. We report that the inhibition of p300/CBP function in the Xenopus embryo abolishes non-neural tissue formation and, strikingly, initiates neural induction and primary neurogenesis in the entire embryo. The observed neuralization is achieved in the absence of anterior or posterior gene expression, suggesting that neural fate activation and anterior patterning may represent distinct molecular events. We further demonstrate that the neuralizing and anteriorizing activities of chordin and noggin are separable properties of these neural inducers. This study reveals that all embryonic cells possess intrinsic neuralizing capability and that p300/CBP function is essential for embryonic germ layer formation and neural fate suppression during vertebrate embryogenesis.
Indexed as
Identifiers
10531441PMC6782909W2136790681What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.