ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Mitochondria regulate the Ca(2+)-exocytosis relationship of bovine adrenal chromaffin cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- Roles for PKC signaling in chromaffin cell exocytosis.Biophysical journal · 2025Article
- Effects of reversible SERCA inhibition on catecholamine exocytosis and intracellular [CaPflugers Archiv : European journal of physiology · 2024Article
- Novel Purine Derivative ITH15004 Facilitates Exocytosis through a Mitochondrial Calcium-Mediated Mechanism.International journal of molecular sciences · 2021Article
- Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases.Cells · 2019Review
- Hydrogen sulphide facilitates exocytosis by regulating the handling of intracellular calcium by chromaffin cells.Pflugers Archiv : European journal of physiology · 2018Article
- Tight mitochondrial control of calcium and exocytotic signals in chromaffin cells at embryonic life.Pflugers Archiv : European journal of physiology · 2015Article
- Non-additive interactions between mitochondrial complex IV blockers and hypoxia in rat carotid body responses.Respiratory physiology & neurobiology · 2014Article
- Novel features on the regulation by mitochondria of calcium and secretion transients in chromaffin cells challenged with acetylcholine at 37°C.Physiological reports · 2013Article
- Regulation by L-type calcium channels of endocytosis: an overview.Journal of molecular neuroscience : MN · 2012Review
- Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells.Pflugers Archiv : European journal of physiology · 2010Article
- Loose coupling between calcium channels and sites of exocytosis in chromaffin cells.The Journal of physiology · 2009Article
- Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.British journal of pharmacology · 2007Article
- Modulation of Ca(2+) release and Ca(2+) oscillations in HeLa cells and fibroblasts by mitochondrial Ca(2+) uniporter stimulation.The Journal of physiology · 2007Article
- Modulation of mitochondrial Ca(2+) uptake by estrogen receptor agonists and antagonists.British journal of pharmacology · 2005Article
- Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids.The Biochemical journal · 2004Article
- Mitochondrial calcium sequestration and protein kinase C cooperate in the regulation of cortical F-actin disassembly and secretion in bovine chromaffin cells.The Journal of physiology · 2004Article
- Modulation of synaptic transmission by the BCL-2 family protein BCL-xL.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Effect of inositol 1,4,5-trisphosphate receptor stimulation on mitochondrial [Ca2+] and secretion in chromaffin cells.The Biochemical journal · 2002Article
- Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The present study expands the contemporary view of mitochondria as important participants in cellular Ca(2+) dynamics and provides evidence that mitochondria regulate the supply of release-competent secretory granules. Using pharmacological probes to inhibit mitochondrial Ca(2+) import, the ability of mitochondria to modulate secretory activity in single, patch-clamped bovine chromaffin cells was examined by simultaneously monitoring rapid changes in membrane surface area (DeltaC(m)) and cytosolic Ca(2+) levels ([Ca(2+)](c)). Repetitive step depolarizations or action potential waveforms were found to raise the [Ca(2+)](c) of chromaffin cells into the 1 microM to tens of micromolar range. Inhibiting mitochondria by treatment with carbonyl cyanide p-(trifuoro-methoxy)phenylhydrazone, antimycin-oligomycin, or ruthenium red revealed that mitochondria are a prominent component for the clearance of Ca(2+) that entered via voltage-activated Ca(2+) channels. Disruption of cellular Ca(2+) homeostasis by poisoning mitochondria enhanced the secretory responsiveness of chromaffin cells by increasing the amplitude of the transient rise and the time course of recovery to baseline of the evoked Delta[Ca(2+)](c). The enhancement of the secretory response was represented by significant deviation of the Ca(2+)-exocytosis relationship from a standard relationship that equates Ca(2+) influx and DeltaC(m). Thus, mitochondria would play a critical role in the control of secretory activity in chromaffin cells that undergo tonic or repetitive depolarizing activity, likely by limiting the Ca(2+)-dependent activation of specific proteins that recruit or prime secretory granules for exocytosis.
Indexed as
Identifiers
10531430PMC6782892W1675974676What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.