ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Multiple and opposing roles of cholinergic transmission in the main olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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Who cites it
72 citing papers in PubMed, 156 citations in OpenAlex.
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- Article
- Top-down acetylcholine signaling via olfactory bulb vasopressin cells contributes to social discrimination in rats.Communications biology · 2021Article
- Multiple Roles for Cholinergic Signaling from the Perspective of Stem Cell Function.International journal of molecular sciences · 2021Review
- Modulation of Neural Microcircuits That Control Complex Dynamics in Olfactory Networks.Frontiers in cellular neuroscience · 2021Article
- Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis.iScience · 2019Article
- Functional Specialization of Interneuron Dendrites: Identification of Action Potential Initiation Zone in Axonless Olfactory Bulb Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Basal forebrain GABAergic innervation of olfactory bulb periglomerular interneurons.The Journal of physiology · 2019Article
- Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning.Frontiers in behavioral neuroscience · 2019Article
- Pharmacological manipulation of the olfactory bulb modulates beta oscillations: testing model predictions.Journal of neurophysiology · 2018Article
- Cholecystokinin selectively activates short axon cells to enhance inhibition of olfactory bulb output neurons.The Journal of physiology · 2018Article
- Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation.Nature communications · 2018Article
- Pain, Headache, and Other Non-motor Symptoms in Myasthenia Gravis.Current pain and headache reports · 2018Review
- Article
- Short-Term Plasticity at Olfactory Cortex to Granule Cell Synapses Requires CaFrontiers in cellular neuroscience · 2018Article
- Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb.Nature communications · 2017Article
- Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have Impaired Odor Discrimination and Learning.Frontiers in synaptic neuroscience · 2017Article
- The effect of bilirubin on the excitability of mitral cells in the olfactory bulb of the rat.Scientific reports · 2016Article
- Biophysical constraints on lateral inhibition in the olfactory bulb.Journal of neurophysiology · 2016Article
- Increased olfactory bulb acetylcholine bi-directionally modulates glomerular odor sensitivity.Scientific reports · 2016Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main olfactory bulb is a critical relay step between the olfactory epithelium and the olfactory cortex. A marked feature of the bulb is its massive innervation by cholinergic inputs from the basal forebrain. In this study, we addressed the functional interaction between cholinergic inputs and intrinsic bulbar circuitry. Determining the roles of acetylcholine (ACh) requires the characterization of cholinergic effects on both neural excitability and synaptic transmission. For this purpose, we used electrophysiological techniques to localize and characterize the diverse roles of ACh in mouse olfactory bulb slices. We found that cholinergic inputs have a surprising number of target receptor populations that are expressed on three different neuronal types in the bulb. Specifically, nicotinic acetylcholine receptors excite both the output neurons of the bulb, i.e., the mitral cells, as well as interneurons located in the periglomerular regions. These nicotine-induced responses in interneurons are short lasting, whereas responses in mitral cells are long lasting. In contrast, muscarinic receptors have an inhibitory effect on the firing rate of interneurons from a deeper layer, granule cells, while at the same time they increase the degree of activity-independent transmitter release from these cells onto mitral cells. Cholinergic signaling thus was found to have multiple and opposing roles in the olfactory bulb. These dual cholinergic effects on mitral cells and interneurons may be important in modulating olfactory bulb output to central structures required for driven behaviors and may be relevant to understanding mechanisms underlying the perturbations of cholinergic inputs to cortex that occur in Alzheimer's disease.
Indexed as
Identifiers
10531421PMC6782910W1776441027What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.