Evidence map›Paper›PMID 10531281›Full record

ArticleInfection and immunity1999

Binding of pili from uropathogenic Escherichia coli to membranes secreted by human colonocytes and enterocytes.

G S Goetz, A Mahmood, S J Hultgren, M J Engle, K Dodson, D H Alpers

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

G S GoetzDepartment of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA.
A Mahmood
S J Hultgren
M J Engle
K Dodson
D H Alpers
Washington University in St. Louis · US

Funding

MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
CHAPERONE-ASSISTED PILI ASSEMBLY IN PATHOGENIC E. COLIR01AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J., YUAN, PENG · 1991 to 2023
$5.7M
CHAPERONE ASSISTED PILI ASSEMBLY IN PATHOGENIC E COLIR37AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 1999 to 2008
$3.2M
INTESTINAL PROTEIN METABOLISM AND FUNCTIONR01DK014038 · NIDDK · WASHINGTON UNIVERSITY · PI ALPERS, DAVID H. · 1986 to 2000
$348k
INTESTINAL SURFACTANT-LIKE PARTICLE--SECRETION &BINDINGF32DK009329 · NIDDK · WASHINGTON UNIVERSITY · PI GOETZ, GEORGE S · 1995 to 1996
–
INTESTINAL PROTEIN METABOLISM &FUNCTIONR37DK014038 · NIDDK · WASHINGTON UNIVERSITY · PI ALPERS, DAVID H. · 1988 to 1995
–
NIAID NIH HHS AI29549NIAID NIH HHS R01 AI029549NIAID NIH HHS R37 AI029549NIDDK NIH HHS DK 14038NIDDK NIH HHS DK51406NIDDK NIH HHS F32 DK009329NIDDK NIH HHS R01 DK051406
6 · The paper itself

Abstract

PapG adhesins mediate the binding of uropathogenic Escherichia coli. Although receptors for these adhesins have not been demonstrated in intestinal epithelia, the colonic microflora includes strains of uropathogenic E. coli. We now report that surfactant-like particles secreted by the human intestine contain receptors for PapG adhesins and may provide an intestinal habitat for uropathogenic bacteria.

Indexed as

Bacterial AdhesionFimbriae ProteinsAdhesins, Escherichia coliColonEnterocytesEscherichia coliFimbriae, BacterialHumansUrinary Tract InfectionsAdhesins, Escherichia coliFimbriae ProteinsPapG protein, E coli

Identifiers

PMID10531281
PMCPMC97007
OpenAlexW2145062229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.