ArticleInfection and immunity1999
Consequence of Nramp1 deletion to Mycobacterium tuberculosis infection in mice.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 77 citations in OpenAlex.
- Model systems to studyFrontiers in cellular and infection microbiology · 2025Review
- Divergent proinflammatory immune responses associated with the differential susceptibility of cattle breeds to tuberculosis.Frontiers in immunology · 2023Article
- Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease.Respiratory research · 2021Review
- The 'Checkmate' for Iron Between Human Host and Invading Bacteria: Chess Game Analogy.Indian journal of microbiology · 2018Review
- Iron and infection.International journal of hematology · 2018Review
- High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis.F1000Research · 2018Article
- Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Gene expression and TB pathogenesis in rhesus macaques: TR4, CD40, CD40L, FAS (CD95), and TNF are host genetic markers in peripheral blood mononuclear cells that are associated with severity of TB lesions.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- Role of B cells and antibodies in acquired immunity against Mycobacterium tuberculosis.Cold Spring Harbor perspectives in medicine · 2014Review
- Host-directed therapeutics for tuberculosis: can we harness the host?Microbiology and molecular biology reviews : MMBR · 2013Review
- Iron in intracellular infection: to provide or to deprive?Frontiers in cellular and infection microbiology · 2013Review
- Innate immune effectors in mycobacterial infection.Clinical & developmental immunology · 2011Review
- Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence.Immunogenetics · 2007Review
- Genetic architecture of tuberculosis resistance in a mouse model of infection.Genes and immunity · 2006Article
- Pathogenesis of Mycobacterium avium infection: typical responses to an atypical mycobacterium?Immunologic research · 2006Review
- NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population.Genes and immunity · 2005Article
- The nature of extracellular iron influences iron acquisition by Mycobacterium tuberculosis residing within human macrophages.Infection and immunity · 2004Article
- Nramp1 deletion does not confer susceptibility to Rhodococcus equi infection in mice.Immunogenetics · 2004Article
- Host genetics and the dissection of mycobacterial immunity.Clinical and experimental immunology · 2004Article
- Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium.Infection and immunity · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
129sv mice functionally deleted of the antimicrobial resistance gene, Nramp1, were found to be as resistant as wild-type mice to infection with the virulent H37Rv strain of Mycobacterium tuberculosis, as determined by monitoring bacterial growth in major organs and recording host survival times. Death of infected mice of both types was associated with extensive infection-induced pathology in the lungs but not in other major organs. These findings are in keeping with the view that Nramp1 is of limited importance in resistance to tuberculosis in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.