Evidence map›Paper›PMID 10529027›Full record

ArticleJournal of clinical epidemiology1999

Further evidence supporting an SEM-based criterion for identifying meaningful intra-individual changes in health-related quality of life.

K W Wyrwich, W M Tierney, F D Wolinsky

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of clinical epidemiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07700225 (Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1), which is not on this map. Cited by 326 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
326citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07700225 recruitingnot on this mapstarted 2026, after this paper: background citation

Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1) Extension

Typeobservational_patient_registrySponsorVirginia Commonwealth UniversityRan2026 to 2032Enrolled1,000ConditionsDM1, Myotonic Dystrophy, Myotonic Dystrophy 1, Myotonic Dystrophy Type 1
3 · Its place in the literature

Who cites it

326 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. A systematic review of minimum important changes for generic multi-attribute utility instruments and recommendations for their estimation.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
    Pooled it
  2. Pooled it
  3. Nd:YAG laser vitreolysis versus pars plana vitrectomy for vitreous floaters.The Cochrane database of systematic reviews · 2017
    Pooled it
  4. Pooled it
  5. Clinical significance in dementia research: a review of the literature.American journal of Alzheimer's disease and other dementias · 2014
    Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

266 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

K W WyrwichSaint Louis University School of Public Health, Missouri 63108-3342, USA. wyrwichk@slu.edu
W M Tierney
F D Wolinsky

Funding

COMPUTER-BASED PROSPECTIVE DRUG UTILIZATION REVIEWR01HS007763 · AHRQ · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TIERNEY, WILLIAM M · 1993 to 1996
–
PANEL ANALYSIS OF THE AGEDS USE OF HEALTH SERVICESR37AG009692 · NIA · SAINT LOUIS UNIVERSITY · PI WOLINSKY, FREDRIC D. · 1990 to 1999
–
AHRQ HHS R01 HS-07763NIA NIH HHS R37 AG-09692
6 · The paper itself

Abstract

This study used the standard error of measurement (SEM) to evaluate intra-individual change on both the Chronic Respiratory Disease Questionnaire (CRQ) and the SF-36. After analyzing the reliability and validity of both instruments at baseline among 471 COPD outpatients, the SEM was compared to established minimal clinically important difference (MCID) standards for three CRQ dimensions. A value of one SEM closely approximated the MCID standards for all CRQ dimensions. This SEM-based criterion was then validated by cross-classifying the change status (improved, stable, or declined) of 393 follow-up outpatients using the one-SEM criterion and the MCID standard. Excellent agreement was achieved for all three CRQ dimensions. Although MCID standards have not been established for the SF-36, the one-SEM criterion was explored in these change scores. Among SF-36 scales demonstrating acceptable reliability and reasonable variance, the percent of individuals within each change category was consistent with those seen in the CRQ dimensions. These results replicate previous findings where a value of one SEM also closely approximated MCIDs for all dimensions of the Chronic Heart Disease Questionnaire among cardiovascular outpatients. The one-SEM criterion should be explored in other health-related quality of life instruments with established MCIDs.

Indexed as

Quality of LifeAdultAgedAged, 80 and overData Interpretation, StatisticalDisease ProgressionFemaleFollow-Up StudiesHealth Status IndicatorsHumansLung Diseases, ObstructiveMaleMiddle AgedOutpatientsReproducibility of ResultsRetrospective Studies

Identifiers

PMID10529027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.