ReviewJournal of mammary gland biology and neoplasia1999
Polyunsaturated fatty acids in human milk and their role in early infant development.
Review in Journal of mammary gland biology and neoplasia, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 146 citations in OpenAlex.
- Trial
- Dietary long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuria: a randomized controlled trial.Journal of inherited metabolic disease · 2007Trial
- Trial
- Comparative Analysis of Signature Lipid Structures in Canine and Feline Milk Compared with Bovine and Caprine Milk.Animals : an open access journal from MDPI · 2026Article
- Breastfeeding and Future Cardiovascular, Kidney, and Metabolic Health-A Narrative Review.Nutrients · 2025Review
- Diabetes-preventive molecular mechanisms of breast versus formula feeding: new insights into the impact of milk on stem cell Wnt signaling.Frontiers in nutrition · 2025Review
- Effect of Holder Pasteurization, Mode of Delivery, and Infant's Gender on Fatty Acid Composition of Donor Breast Milk.Nutrients · 2024Article
- Maternal childhood trauma is associated with offspring body size during the first year of life.Scientific reports · 2022Article
- Fatty Acid Composition of Milk from Mothers with Normal Weight, Obesity, or Gestational Diabetes.Life (Basel, Switzerland) · 2022Article
- Near-Infrared Sensors for Onsite and Noninvasive Quantification of Macronutrients in Breast Milk.Sensors (Basel, Switzerland) · 2022Article
- Analysis and Comparison of Nutrition Profiles of Canine Milk with Bovine and Caprine Milk.Foods (Basel, Switzerland) · 2022Article
- Article
- The Fatty Acid Species and Quantity Consumed by the Breastfed Infant Are Important for Growth and Development.Nutrients · 2021Article
- Human Milk Microbiota and Oligosaccharides: A Glimpse into Benefits, Diversity, and Correlations.Nutrients · 2021Review
- Untargeted lipidomics using liquid chromatography-ion mobility-mass spectrometry reveals novel triacylglycerides in human milk.Scientific reports · 2020Article
- Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study.The American journal of clinical nutrition · 2019Article
- Quantification of Human Milk Phospholipids: the Effect of Gestational and Lactational Age on Phospholipid Composition.Nutrients · 2019Article
- Temporal Progression of Fatty Acids in Preterm and Term Human Milk of Mothers from Switzerland.Nutrients · 2019Article
- Raman spectroscopy combined with a support vector machine for differentiating between feeding male and female infants mother's milk.Biomedical optics express · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lipid fraction of human milk represents the main source of energy for the newborn infant and supplies essential nutrients such as fat-soluble vitamins and polyunsaturated fatty acids (PUFA). The essential fatty acids linoleic and alpha-linolenic acids are precursors of long-chain polyunsaturated fatty acids (LC-PUFA), such as arachidonic (C20:4 n-6) and docosahexaenoic (C22:6 n-3) acids, present in human milk in considerable amounts. LC-PUFA are indispensable structural components of all cellular membranes, and they are incorporated in relatively large amounts during early growth of the brain and the retina. Moreover, some LC-PUFA are precursors of eicosanoids, molecules with potent biological activity that modulates various cellular and tissue processes. The supply of long-chain fatty acids has been associated with functional outcomes of the recipient infants such as visual acuity and development of cognitive functions during the first year of life. Here we discuss the PUFA composition of human milk, factors which determine and modulate milk PUFA content, and possible effects of milk LC-PUFA on infant growth and development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.