ArticleJournal of molecular neuroscience : MN1999
Identification of 3'UTR region implicated in tau mRNA stabilization in neuronal cells.
Article in Journal of molecular neuroscience : MN, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 58 citations in OpenAlex.
- Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex.Nature neuroscience · 2026Article
- The Role of Tau in Neuronal Function and Neurodegeneration.Neurology international · 2025Review
- Posttranscriptional regulation of neurofilament proteins and tau in health and disease.Brain research bulletin · 2023Review
- Intra-axonal mechanisms driving axon regeneration.Brain research · 2020Review
- Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212.Frontiers in neurology · 2020Article
- Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body.Neuron · 2019Article
- Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.Nucleic acids research · 2019Article
- The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology.PloS one · 2019Article
- Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Molecular neurodegeneration · 2017Article
- A UV cross-linking method combined with infrared imaging to analyse RNA-protein interactions.Biology methods & protocols · 2017Article
- Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1.Nucleic acids research · 2015Article
- Regulation of human MAPT gene expression.Molecular neurodegeneration · 2015Review
- Molecular determinants of the axonal mRNA transcriptome.Developmental neurobiology · 2014Review
- Deep sequencing and high-resolution imaging reveal compartment-specific localization of Bdnf mRNA in hippocampal neurons.Science signaling · 2013Article
- Alternative polyadenylation and miR-34 family members regulate tau expression.Journal of neurochemistry · 2013Article
- A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element.Journal of neurochemistry · 2013Article
- The MAPT H1 haplotype is associated with tangle-predominant dementia.Acta neuropathologica · 2012Article
- Hu antigen R and tristetraprolin: counter-regulators of rat apical sodium-dependent bile acid transporter by way of effects on messenger RNA stability.Hepatology (Baltimore, Md.) · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tau, a neuronal microtubule-associated protein (MAP) plays an important role in the formation and maintenance of neuronal polarity. Tau mRNA is a stable message and exhibits a relatively long half-life in neuronal cells. The regulation of mRNA stability is a crucial determinant in controlling mRNA steady-state levels in neuronal cells and thereby influences gene expression. The half-lives of specific mRNAs may be dependent on specific sequences located at their 3'untranslated region (UTR), which in turn, may be recognized by tissue-specific proteins. To identify the sequence elements involved in tau mRNA stabilization, selected regions of the 3'UTR were subcloned downstream to c-fos reporter mRNA or to the coding region of the tau mRNA. Using stably transfected neuronal cells, we have demonstrated that a fragment of 240 bp (H fragment) located in the 3'UTR can stabilize c-fos and tau mRNAs. Analysis of stably transfected cells indicated that the transfected tau mRNAs are associated with the microtubules of neuronal cells, suggesting that this association may play a role in tau mRNA stabilization. This step may be a prerequisite in the multistep process leading to the subcellular localization of tau mRNA in neuronal cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.