ReviewThe Yale journal of biology and medicine
Aging and reproductive potential in women.
Review in The Yale journal of biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- Trial
- Germ cells and the aging niche: a systems approach to reproductive longevity.Journal of assisted reproduction and genetics · 2025Review
- Stem cell-based therapeutic potential in female ovarian aging and infertility.Journal of ovarian research · 2024Review
- Oocyte Health and Quality: Implication of Mitochondria-related Organelle Interactions.Results and problems in cell differentiation · 2024Review
- Differential age-related transcriptomic analysis of ovarian granulosa cells in Kazakh horses.Frontiers in endocrinology · 2024Article
- Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst, and stromal cell decidualization, in mice.Molecular human reproduction · 2022Article
- Coenzyme Q10 levels increase with embryonic development in medaka.Journal of clinical biochemistry and nutrition · 2022Article
- Effect of intra-ovarian injection of mesenchymal stem cells in aged mares.Journal of assisted reproduction and genetics · 2019Article
- The Effect of Advanced Maternal Age on Embryo Morphokinetics.Frontiers in endocrinology · 2019Article
- The Role of RFamide-Related Peptide-3 in Age-Related Reproductive Decline in Female Rats.Frontiers in endocrinology · 2016Article
- The role of oxidative stress in menopause.Journal of mid-life health · 2013Review
- Sex and gonadal hormones in mouse models of Alzheimer's disease: what is relevant to the human condition?Biology of sex differences · 2012Article
- Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent model.Neuroendocrinology · 2012Review
- Parental age and lifespan influence offspring recruitment: a long-term study in a seabird.PloS one · 2011Article
- Is a decline in offspring quality a necessary consequence of maternal age?Proceedings. Biological sciences · 2003Article
- Reproductive aging and mating: the ticking of the biological clock in female cockroaches.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Significant effects of mild endogenous hormonal changes in humans: considerations for low-dose testing.Environmental health perspectives · 2001Review
- A Comparison of Body Composition Across Two Phases of the Menstrual Cycle Utilizing Dual-Energy X-Ray Absorptiometry, Air Displacement Plethysmography, and Bioelectrical Impedance Analysis.International journal of exercise scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reproductive potential in women declines with age. Age-related changes in the ovary account for most of this loss of reproductive function. Oocytes, all of which are present at birth, decline in number and quality with age. The endocrine function of the ovary also declines with age, and the ovary becomes unable to sustain its normal function in the neuroendocrine axis. The neuroendocrine axis may be further affected by primary changes occurring in the hypothalamus and pituitary during aging, although this has not been established in humans. Aging also affects the function of the uterus as the endometrium loses its ability to support implantation and growth of an embryo. Diminished uterine function during aging may be due to changes in the uterine vasculature or to changes in the hormone-dependent development of the endometrium. Finally, aging increases a woman's risk of developing medical, gynecologic or obstetric conditions that may impair her fertility. Knowledge of these affects of aging on a woman's reproductive function is essential to advise and treat the growing number of women seeking pregnancy at advanced reproductive age.
Indexed as
Identifiers
10527364PMC2578931W2412758230What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.