ArticleThe Journal of cell biology1999
The receptor tyrosine phosphatase CRYPalpha promotes intraretinal axon growth.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Signaling - transcription interactions in mouse retinal ganglion cells early axon pathfinding -a literature review.Frontiers in ophthalmology · 2023Review
- Advances in the Signaling Pathways Downstream of Glial-Scar Axon Growth Inhibitors.Frontiers in cellular neuroscience · 2020Review
- Mechanisms of PTPσ-Mediated Presynaptic Differentiation.Frontiers in synaptic neuroscience · 2019Article
- Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Molecular mechanisms of scar-sourced axon growth inhibitors.Brain research · 2015Review
- Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.Seminars in cell & developmental biology · 2015Review
- Traffic lights for axon growth: proteoglycans and their neuronal receptors.Neural regeneration research · 2014Article
- Scar-mediated inhibition and CSPG receptors in the CNS.Experimental neurology · 2012Review
- Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner.Molecular and cellular neurosciences · 2012Article
- Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.Science (New York, N.Y.) · 2011Article
- Protein tyrosine phosphatases expression during development of mouse superior colliculus.Experimental brain research · 2009Article
- Rho GTPases regulate PTPmu-mediated nasal neurite outgrowth and temporal repulsion of retinal ganglion cell neurons.Molecular and cellular neurosciences · 2007Article
- N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth.Molecular and cellular biology · 2007Article
- Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-sigma.The FEBS journal · 2006Article
- Receptor tyrosine phosphatases guide vertebrate motor axons during development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Sonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in receptor protein tyrosine phosphatase sigma knock-out mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Chick PTPsigma regulates the targeting of retinal axons within the optic tectum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Protein tyrosine phosphatase-mu differentially regulates neurite outgrowth of nasal and temporal neurons in the retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma.Molecular and cellular biology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal ganglion cell axons grow towards the optic fissure in close contact with the basal membrane, an excellent growth substratum. One of the ligands of receptor tyrosine phosphatase CRYPalpha is located on the retinal and tectal basal membranes. To analyze the role of this RPTP and its ligand in intraretinal growth and guidance of ganglion cell axons, we disrupted ligand- receptor interactions on the retinal basal membrane in culture. Antibodies against CRYPalpha strongly reduced retinal axon growth on the basal membrane, and induced a dramatic change in morphology of retinal growth cones, reducing the size of growth cone lamellipodia. A similar effect was observed by blocking the ligand with a CRYPalpha ectodomain fusion protein. These effects did not occur, or were much reduced, when axons were grown either on laminin-1, on matrigel or on basal membranes with glial endfeet removed. This indicates that a ligand for CRYPalpha is located on glial endfeet. These results show for the first time in vertebrates that the interaction of a receptor tyrosine phosphatase with its ligand is crucial not only for promotion of retinal axon growth but also for maintenance of retinal growth cone lamellipodia on basal membranes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.