ArticleOncogene1999
Dissociation of the recombination control and the sequence-specific transactivation function of P53.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 88 citations in OpenAlex.
- Canonical and non-canonical functions of p53 isoforms: potentiating the complexity of tumor development and therapy resistance.Cell death & disease · 2024Review
- Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage.Cell death & disease · 2022Article
- p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway.Cell death & disease · 2021Article
- Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.Nucleic acids research · 2020Article
- An LTR retrotransposon-derived lncRNA interacts with RNF169 to promote homologous recombination.EMBO reports · 2019Article
- Transcriptional activation of p21Oncotarget · 2018Article
- One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain.Biophysical journal · 2017Article
- Influence of Human p53 on Plant Development.PloS one · 2016Article
- p53 Specifically Binds Triplex DNA In Vitro and in Cells.PloS one · 2016Article
- p53 suppresses hyper-recombination by modulating BRCA1 function.DNA repair · 2015Article
- p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation.Oncogene · 2013Article
- Chromosome instability and deregulated proliferation: an unavoidable duo.Cellular and molecular life sciences : CMLS · 2012Review
- Article
- Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Review
- Regulation of MCP-1 chemokine transcription by p53.Molecular cancer · 2010Article
- p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene.EMBO reports · 2006Article
- Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination.Oncogene · 2005Article
- Wild-type p53 stimulates homologous recombination upon sequence-specific binding to the ribosomal gene cluster repeat.Oncogene · 2005Article
- The interaction of p53 with replication protein A mediates suppression of homologous recombination.Oncogene · 2004Article
- p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, we described a new biological function of p53 in inhibiting recombination processes when encountering mismatches in heteroduplexes (Dudenhöffer et al., 1998). Here, we characterized protein domains of p53 participating in this process by in vitro analysis of mutated p53 proteins, and by applying our SV40-based assay system on monkey cells, which express different p53 variants. We present evidence that both binding of artificial recombination intermediates and p53-dependent recombination control require an intact p53 core and the oligomerization domain, strongly suggesting that the recognition of DNA undergoing recombination represents an essential step of this genomic surveillance mechanism. Further analyses indicated a role of the C-terminus in negatively regulating recombination control, an effect which can be neutralized by concurrent mismatch recognition. p53 lacking the oligomerization domain totally lost its ability to suppress homologous recombination. The cancer-related mutant p53(273H) was also significantly defective in this function, although we observed only twofold reductions in the corresponding transactivation activities on p53-response elements in episomal constructs. HDM2, an inhibitor of p53's transcriptional and growth regulatory activities, interfered with the inhibition of DNA exchange processes by p53 only weakly. Thus, functions of p53 in recombination control can be structurally dissociated from p53-dependent transcriptional transactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.