ArticleMolecular and cellular biology1999
The levels of the bancal product, a Drosophila homologue of vertebrate hnRNP K protein, affect cell proliferation and apoptosis in imaginal disc cells.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Host Restriction Factor A3G Inhibits the Replication of Enterovirus D68 by Competitively Binding the 5' Untranslated Region with PCBP1.Journal of virology · 2022Article
- RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.Molecular and cellular biology · 2021Article
- hnRNP K Supports High-Amplitude D Site-Binding Protein mRNA (Molecular and cellular biology · 2020Article
- miR-7 Buffers Differentiation in the Developing Drosophila Visual System.Cell reports · 2017Article
- The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.Molecular and cellular biology · 2016Article
- K-homology nuclear ribonucleoproteins regulate floral organ identity and determinacy in arabidopsis.PLoS genetics · 2015Article
- hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells.PLoS genetics · 2015Article
- Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation.Nucleic acids research · 2014Article
- Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Human molecular genetics · 2011Article
- Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology.PloS one · 2011Article
- The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila.Genetics · 2009Article
- Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing.Nucleic acids research · 2009Article
- Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells.Development (Cambridge, England) · 2009Article
- Heat shock genes - integrating cell survival and death.Journal of biosciences · 2007Review
- Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer.British journal of cancer · 2006Article
- Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Nuclear shift of hnRNP K protein in neoplasms and other states of enhanced cell proliferation.British journal of cancer · 2003Article
- Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci.Nucleic acids research · 2003Article
- The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms.RNA (New York, N.Y.) · 2002Review
- An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis.Genetics · 2000Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have characterized the Drosophila bancal gene, which encodes a Drosophila homologue of the vertebrate hnRNP K protein. The bancal gene is essential for the correct size of adult appendages. Reduction of appendage size in bancal mutant flies appears to be due mainly to a reduction in the number of cell divisions in the imaginal discs. Transgenes expressing Drosophila or human hnRNP K are able to rescue weak bancal phenotype, showing the functional similarity of these proteins in vivo. High levels of either human or Drosophila hnRNP K protein in imaginal discs induces programmed cell death. Expression of the antiapoptotic P35 protein suppresses this phenotype in the eye, suggesting that apoptosis is the major cellular defect caused by overexpression of K protein. Finally, the human K protein acts as a negative regulator of bancal gene expression. We propose that negative autoregulation limits the level of Bancal protein produced in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.