ArticleMolecular and cellular biology1999
Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage?
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- Runs of Homozygosity Uncover Potential Functional-Altering Mutation Associated With Body Weight and Length in Two Duroc Pig Lines.Frontiers in veterinary science · 2022Article
- The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus?European journal of medical research · 2021Review
- Decorin regulates cartilage pericellular matrix micromechanobiology.Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis.International journal of molecular sciences · 2020Article
- Review of the Genetic Basis of Jaw Malformations.Journal of pediatric genetics · 2016Review
- Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4.The Journal of experimental medicine · 2016Article
- Extracellular matrix and developing growth plate.Current osteoporosis reports · 2014Review
- Matrilin-1 is essential for zebrafish development by facilitating collagen II secretion.The Journal of biological chemistry · 2014Article
- Joint TGF-β type II receptor-expressing cells: ontogeny and characterization as joint progenitors.Stem cells and development · 2013Article
- Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation.Arthritis and rheumatism · 2012Article
- Twinfilin-2a is dispensable for mouse development.PloS one · 2011Article
- Structural and functional investigations of Matrilin-1 A-domains reveal insights into their role in cartilage ECM assembly.The Journal of biological chemistry · 2010Article
- Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.Human molecular genetics · 2007Article
- Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms.Developmental biology · 2007Article
- Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis.The American journal of pathology · 2006Article
- Zebrafish (Danio rerio) matrilins: shared and divergent characteristics with their mammalian counterparts.The Biochemical journal · 2005Article
- Tenomodulin is necessary for tenocyte proliferation and tendon maturation.Molecular and cellular biology · 2005Article
- Matrilin-3 is dispensable for mouse skeletal growth and development.Molecular and cellular biology · 2004Article
- Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.Genes & development · 2003Article
- Matrilin-2 interacts with itself and with other extracellular matrix proteins.The Biochemical journal · 2002Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrilin 1, or cartilage matrix protein, is a member of a novel family of extracellular matrix proteins. To date, four members of the family have been identified, but their biological role is unknown. Matrilin 1 and matrilin 3 are expressed in cartilage, while matrilin 2 and matrilin 4 are present in many tissues. Here we describe the generation and analysis of mice carrying a null mutation in the Crtm gene encoding matrilin 1. Anatomical and histological studies demonstrated normal development of homozygous mutant mice. Northern blot and biochemical analyses show no compensatory up-regulation of matrilin 2 or 3 in the cartilage of knockout mice. Although matrilin 1 interacts with the collagen II and aggrecan networks of cartilage, suggesting that it may play a role in cartilage tissue organization, studies of collagen extractability indicated that collagen fibril maturation and covalent cross-linking were unaffected by the absence of matrilin 1. Ultrastructural analysis did not reveal any abnormalities of matrix organization. These data suggest that matrilin 1 is not critically required for cartilage structure and function and that matrilin 1 and matrilin 3 may have functionally redundant roles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.