ArticleMolecular and cellular biology1999
Control of meiotic recombination and gene expression in yeast by a simple repetitive DNA sequence that excludes nucleosomes.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- The impact of poly-A microsatellite heterologies in meiotic recombination.Life science alliance · 2019Article
- The effects of transcription and recombination on mutational dynamics of short tandem repeats.Nucleic acids research · 2018Article
- Functional Mechanisms of Microsatellite DNA in Eukaryotic Genomes.Genome biology and evolution · 2017Review
- Crossing-over in a hypervariable species preferentially occurs in regions of high local similarity.Molecular biology and evolution · 2014Article
- The Drosophila early ovarian transcriptome provides insight to the molecular causes of recombination rate variation across genomes.BMC genomics · 2013Article
- The role of CSM3, MRC1, and TOF1 in minisatellite stability and large loop DNA repair during meiosis in yeast.Fungal genetics and biology : FG & B · 2013Article
- Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast.The EMBO journal · 2012Article
- Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.Genome research · 2012Article
- Genomic structure of and genome-wide recombination in the Saccharomyces cerevisiae S288C progenitor isolate EM93.PloS one · 2011Article
- Genomic signatures of germline gene expression.Genome research · 2010Article
- Mutational dynamics of microsatellites.Molecular biotechnology · 2010Review
- Recombination and its impact on the genome of the haplodiploid parasitoid wasp Nasonia.PloS one · 2010Article
- A positive but complex association between meiotic double-strand break hotspots and open chromatin in Saccharomyces cerevisiae.Genome research · 2009Article
- Novel nucleotide sequence motifs that produce hotspots of meiotic recombination in Schizosaccharomyces pombe.Genetics · 2009Article
- Sites of strong Rec12/Spo11 binding in the fission yeast genome are associated with meiotic recombination and with centromeres.Chromosoma · 2008Article
- Article
- Discovery of a new HBB haplotype w2 in a wild-derived house mouse, Mus musculus.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination.Nucleic acids research · 2008Article
- High frequency of microsatellites in S. cerevisiae meiotic recombination hotspots.BMC genomics · 2008Article
- Meiotic crossover number and distribution are regulated by a dosage compensation protein that resembles a condensin subunit.Genes & development · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Tandem repeats of the pentanucleotide 5'-CCGNN (where N indicates any base) were previously shown to exclude nucleosomes in vitro (Y. -H. Wang and J. D. Griffith, Proc. Natl. Acad. Sci. USA 93:8863-8867, 1996). To determine the in vivo effects of these sequences, we replaced the upstream regulatory sequences of the HIS4 gene of Saccharomyces cerevisiae with either 12 or 48 tandem copies of CCGNN. Both tracts activated HIS4 transcription. We found that (CCGNN)(12) tracts elevated meiotic recombination (hot spot activity), whereas the (CCGNN)(48) tract repressed recombination (cold spot activity). In addition, a "pure" tract of (CCGAT)(12) activated both transcription and meiotic recombination. We suggest that the cold spot activity of the (CCGNN)(48) tract is related to the phenomenon of the suppressive interactions of adjacent hot spots previously described in yeast (Q.-Q. Fan, F. Xu, and T. D. Petes, Mol. Cell. Biol. 15:1679-1688, 1995; Q.-Q. Fan, F. Xu, M. A. White, and T. D. Petes, Genetics 145:661-670, 1997; T.-C. Wu and M. Lichten, Genetics 140:55-66, 1995; L. Xu and N. Kleckner, EMBO J. 16:5115-5128, 1995).
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