ArticleThe Journal of experimental medicine1999
The Src family tyrosine kinase Fyn regulates natural killer T cell development.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 182 citations in OpenAlex.
- Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data.Seminars in immunology · 2022Review
- Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge.Nature reviews. Immunology · 2020Review
- SLAM-SAP-Fyn: Old Players with New Roles in iNKT Cell Development and Function.International journal of molecular sciences · 2019Review
- Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy.International journal of molecular sciences · 2019Review
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells.Frontiers in immunology · 2019Review
- SOX4 controls invariant NKT cell differentiation by tuning TCR signaling.The Journal of experimental medicine · 2018Article
- X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective.Frontiers in immunology · 2018Review
- Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood.Epigenetics · 2015Article
- Antitumor Responses of Invariant Natural Killer T Cells.Journal of immunology research · 2015Review
- Generation of induced pluripotent stem cell-derived mice by reprogramming of a mature NKT cell.International immunology · 2014Article
- Disposal of iNKT cell deficiency and an increase in expression of SLAM signaling factors characterizes sarcoidosis remission: a 4-year longitudinal study.Respiratory research · 2014Article
- Large granular lymphocytosis during dasatinib therapy.Cancer biology & therapy · 2014Review
- SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors.Frontiers in immunology · 2014Article
- Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation.Diabetes · 2013Article
- Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Diacylglycerol kinases: regulated controllers of T cell activation, function, and development.International journal of molecular sciences · 2013Review
- CD36 and Fyn kinase mediate malaria-induced lung endothelial barrier dysfunction in mice infected with Plasmodium berghei.PloS one · 2013Article
- Role of diacylglycerol kinases in T cell development and function.Critical reviews in immunology · 2013Review
- The transcriptional repressor NKAP is required for the development of iNKT cells.Nature communications · 2013Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T lymphocytes express two Src tyrosine kinases, Lck and Fyn. While thymocyte and T cell subsets are largely normal in fyn(-/-) mice, animals lacking Lck have impaired T cell development. Here, it is shown that Fyn is required for the rapid burst of interleukin (IL)-4 and IL-13 synthesis, which occurs promptly after T cell receptor activation. The lack of cytokine induction in fyn mutant mice is due to a block in natural killer (NK) T cell development. Studies using bone marrow chimeras indicate that the defect behaves in a cell-autonomous manner, and the lack of NK T cells is probably not caused by inappropriate microenvironmental cues. Both NK T cells and conventional T cells express similar levels of Lck, implying that Fyn and Lck have distinct roles in regulating NK T cell ontogeny. The fyn mutation defines the first signaling molecule that is selectively required for NK T cell, but not for T lymphocyte or NK cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.