ArticleThe Journal of experimental medicine1999
Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 45 citations in OpenAlex.
- Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Understanding signal integration through targeted mutations of an adapter protein.FEBS letters · 2010Article
- Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment.Seminars in immunology · 2010Review
- Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells.The Journal of experimental medicine · 2006Article
- Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection.The Journal of experimental medicine · 2005Article
- The biological activity of natural and mutant pTalpha alleles.The Journal of experimental medicine · 2001Article
- Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Signaling via the pre-T cell receptor (TCR) is required for the proliferative expansion and maturation of CD4(-)CD8(-) double-negative (DN) thymocytes into CD4(+)CD8(+) double-positive (DP) cells and for TCR-beta allelic exclusion. The adaptor protein SH2 domain-containing leukocyte protein (SLP)-76 has been shown to play a crucial role in thymic development, because thymocytes of SLP-76(-/-) mice are arrested at the CD25(+)CD44(-) DN stage. Here we show that SLP-76(-/-) DN thymocytes express the pre-TCR on their surfaces and that introduction of a TCR-alpha/beta transgene into the SLP-76(-/-) background fails to cause expansion of DN thymocytes or developmental progression to the DP stage. Moreover, analysis of TCR-beta rearrangement in SLP-76(-/-) TCR-transgenic mice or in single CD25(+)CD44(-) DN cells from SLP-76(-/-) mice indicates an essential role of SLP-76 in TCR-beta allelic exclusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.