ArticleJournal of clinical microbiology1999
Biotyping and virulence properties of skin isolates of Candida parapsilosis.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 88 citations in OpenAlex.
- [Fungal peritoneal dialysis catheter-related exit-site infection combined with tunnel infection: A case report].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Virulence Factors and Antifungal Susceptibility in Candida Species Isolated from Dermatomycosis Patients.Mycopathologia · 2021Article
- Article
- Mechanisms of PathogenicFrontiers in cellular and infection microbiology · 2020Review
- Candida parapsilosis Vaginal Infection-a New Site of Azole Drug Resistance.Current infectious disease reports · 2018Review
- Survival, Persistence, and Isolation of the Emerging Multidrug-Resistant Pathogenic Yeast Candida auris on a Plastic Health Care Surface.Journal of clinical microbiology · 2017Article
- Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens.Journal of biomedical science · 2017Article
- Adhesion ofFood technology and biotechnology · 2017Article
- The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome.Journal of microbial & biochemical technology · 2016Article
- Isolation and identification of Candida species in patients with orogastric cancer: susceptibility to antifungal drugs, attributes of virulence in vitro and immune response phenotype.BMC infectious diseases · 2016Article
- Sulfone derivatives reduce growth, adhesion and aspartic protease SAP2 gene expression.World journal of microbiology & biotechnology · 2014Article
- Candida virulence properties and adverse clinical outcomes in neonatal candidiasis.The Journal of pediatrics · 2012Article
- Candida parapsilosis and the neonate: epidemiology, virulence and host defense in a unique patient setting.Expert review of anti-infective therapy · 2012Review
- In vitro evaluation of phospholipase, proteinase, and esterase activities of Candida parapsilosis and Candida metapsilosis.Mycopathologia · 2011Article
- Isolates from hospital environments are the most virulent of the Candida parapsilosis complex.BMC microbiology · 2011Article
- Investigation of extracellular phospholipase and proteinase activities of Candida species isolated from individuals denture wearers and genotypic distribution of Candida albicans strains.Current microbiology · 2011Article
- Inhibition of virulence factors of Candida spp. by different surfactants.Mycopathologia · 2011Article
- Article
- New polymorphic microsatellite markers able to distinguish among Candida parapsilosis sensu stricto isolates.Journal of clinical microbiology · 2010Article
- Biology and genetics of the pathogenic yeast Candida parapsilosis.Current genetics · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biotype and virulence of skin isolates of Candida parapsilosis were compared with blood isolates of the same fungus. Morphotype, resistotype, and electrophoretic karyotype determinations did not reveal any special cluster with a unique or dominant pathogenic feature among all of the isolates, regardless of their source. However, all cutaneous isolates had uniformly elevated secretory aspartyl-protease (Sap) activity, more than four times higher than the enzyme activity of the blood isolates. They were also highly vaginopathic in a rat vaginitis model, being significantly more virulent than blood isolates in this infection model. In contrast, skin isolates were nonpathogenic in systemic infection of cyclophosphamide-immunodepressed mice, while some blood isolates were, in this model, highly pathogenic (median survival time, 2 days, with internal organ invasion at autopsy). Finally, skin isolates did not differ, as a whole, from blood isolates in their adherence to plastic. This property was associated with a morphotype, as defined by a colony with continuous fringe, which was present among both skin and blood isolates. While confirming the genetic heterogenicity of C. parapsilosis, our data strongly suggest that the potential of this fungus to cause mucosal disease is associated with Sap production and is substantially distinct from that of systemic invasion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.