ArticleGenome research1999
Human genome anatomy: BACs integrating the genetic and cytogenetic maps for bridging genome and biomedicine.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Oxytocin and our place in the universe.Comprehensive psychoneuroendocrinology · 2024Review
- Development of chromosomal markers based on next-generation sequencing: the B chromosome of the cichlid fish Astatotilapia latifasciata as a model.BMC genetics · 2016Article
- The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Phylogenomics of species from four genera of New World monkeys by flow sorting and reciprocal chromosome painting.BMC evolutionary biology · 2007Article
- A new platform linking chromosomal and sequence information.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
- Article
- Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Refined physical map of the human PAX2/HOX11/NFKB2 cancer gene region at 10q24 and relocalization of the HPV6AI1 viral integration site to 14q13.3-q21.1.BMC genomics · 2003Article
- Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes.Nucleic acids research · 2002Article
- Current status of human chromosome 14.Journal of medical genetics · 2002Review
- Sequence-based design of single-copy genomic DNA probes for fluorescence in situ hybridization.Genome research · 2001Article
- Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.American journal of human genetics · 2001Article
- Article
- Additional complexity on human chromosome 15q: identification of a set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and 15q26.Genome research · 2001Article
- A comprehensive BAC resource.Nucleic acids research · 2001Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Human genome sequencing is accelerating rapidly. Multiple genome maps link this sequence to problems in biology and clinical medicine. Because each map represents a different aspect of the structure, content, and behavior of human chromosomes, these fundamental properties must be integrated with the genome to understand disease genes, cancer instability, and human evolution. Cytogenetic maps use 400-850 visible band landmarks and are the primary means for defining prenatal defects and novel cancer breakpoints, thereby providing simultaneous examination of the entire genome. Recent genetic, physical, and transcript maps use PCR-based landmarks called sequence-tagged sites (STSs). We have integrated these genome maps by anchoring the human cytogenetic to the STS-based genetic and physical maps with 1021 STS-BAC pairs at an average spacing of approximately 1 per 3 Mb. These integration points are represented by 872 unique STSs, including 642 polymorphic markers and 957 bacterial artificial chromosomes (BACs), each of which was localized on high resolution fluorescent banded chromosomes. These BACs constitute a resource that bridges map levels and provides the tools to seamlessly translate questions raised by genomic change seen at the chromosomal level into answers based at the molecular level. We show how the BACs provide molecular links for understanding human genomic duplications, meiosis, and evolution, as well as reagents for conducting genome-wide prenatal diagnosis at the molecular level and for detecting gene candidates associated with novel cancer breakpoints.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.