ArticleThe Journal of physiology1999
Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 87 citations in OpenAlex.
- Principles and properties of ion flow in P2X receptors.Frontiers in cellular neuroscience · 2014Review
- A novel population of subepithelial platelet-derived growth factor receptor α-positive cells in the mouse and human colon.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Vascular endothelial cells mediate mechanical stimulation-induced enhancement of endothelin hyperalgesia via activation of P2X2/3 receptors on nociceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Review
- Mast cells drive mesenteric afferent signalling during acute intestinal ischaemia.The Journal of physiology · 2011Article
- Deletion of P2X3 receptors blunts gastro-oesophageal sensation in mice.Neurogastroenterology and motility · 2009Article
- Distribution of P2X(3) receptor immunoreactivity in myenteric ganglia of the mouse esophagus.Histochemistry and cell biology · 2009Article
- P2X3 receptor involvement in pain states.Molecular neurobiology · 2007Review
- Increased 5-HT(3)-mediated signalling in pelvic afferent neurons from mice deficient in P2X(2) and/or P2X (3) receptor subunits.Purinergic signalling · 2006Article
- Pharmacology of P2X channels.Pflugers Archiv : European journal of physiology · 2006Review
- P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP.The Journal of physiology · 2005Article
- Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice.The Journal of physiology · 2005Article
- Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats.The Journal of physiology · 2005Article
- Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome.British journal of pharmacology · 2004Review
- P2X3 receptors and peripheral pain mechanisms.The Journal of physiology · 2004Review
- Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats.The Journal of physiology · 2003Article
- ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder.The Journal of physiology · 2002Article
- Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin.The Journal of physiology · 2001Article
- Mechanism of prolonged vasorelaxation to ATP in the rat isolated mesenteric arterial bed.British journal of pharmacology · 2001Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
1. We examined the effects of P2X purinoceptor agonists and P2 purinoceptor antagonists on mesenteric afferent nerves supplying the jejunum in the pentobarbitone sodium-anaesthetised rat. 2. ATP (0. 01-10 mg kg-1, i.a.) and alpha,beta-methylene-ATP (1-30 microg kg-1, i.a.) each induced dose-dependent increases in afferent nerve discharge and intrajejunal pressure. The effect on afferent nerves comprised an early (< 2 s after administration) intense burst of activity followed by a later increase (> 2 s after administration), less pronounced in comparison, which coincided with elevated intrajejunal pressure. 3. Pyridoxalphosphate-6-azophenyl-2', 4'-disulphonic acid (20 mg kg-1, i.v.) and suramin (80 mg kg-1, i.v. ) each antagonised both the early and later increases in afferent nerve discharge elicited by alpha,beta-methylene-ATP (30 microg kg-1, i.a.). 4. Co-administration of omega-conotoxin MVIIA and omega-conotoxin SVIB (each at 25 microg kg-1, i.v.), or treatment with the selective 5-HT3 receptor antagonist alosetron (30 microg kg-1, i.v.), did not affect the rapid burst of afferent nerve activity elicited by alpha,beta-methylene-ATP (30 microg kg-1, i.a.). However, toxin treatment did attenuate the elevations in intrajejunal pressure and the corresponding later phases of evoked afferent discharge, while alosetron inhibited basal afferent nerve activity. 5. In summary, ATP and alpha,beta-methylene-ATP each evoke excitation of mesenteric afferent nerves in the anaesthetised rat. We propose that the early increase in mesenteric afferent nerve activity represents a direct effect on the nerve ending, mediated by P2X receptors, whereas the later increase reflects activation of mechanosensitive fibres secondary to elevated intrajejunal pressure.
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