ArticleThe Journal of physiology1999
Expression and polarized distribution of an inwardly rectifying K+ channel, Kir4.1, in rat retinal pigment epithelium.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium.Stem cells translational medicine · 2022Article
- Focus on Kir7.1: physiology and channelopathy.Channels (Austin, Tex.) · 2014Review
- Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A genome-wide linkage scan in Tunisian families identifies a novel locus for non-syndromic posterior microphthalmia to chromosome 2q37.1.Human genetics · 2009Article
- Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium.Experimental eye research · 2008Article
- Modulation of the heteromeric Kir4.1-Kir5.1 channel by multiple neurotransmitters via Galphaq-coupled receptors.Journal of cellular physiology · 2008Article
- Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel.Biochimica et biophysica acta · 2007Article
- Contribution of Kir4.1 to the mouse electroretinogram.Molecular vision · 2004Article
- Regulation of inwardly rectifying K+ channels in retinal pigment epithelial cells by intracellular pH.The Journal of physiology · 2003Article
- An inwardly rectifying K+ channel in bovine parotid acinar cells: possible involvement of Kir2.1.The Journal of physiology · 2003Article
- Expression and permeation properties of the K(+) channel Kir7.1 in the retinal pigment epithelium.The Journal of physiology · 2001Article
- Functional Kir7.1 channels localized at the root of apical processes in rat retinal pigment epithelium.The Journal of physiology · 2001Article
- Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. In the eye, different substances and ions including potassium (K+) are transported between neural retina and choroid via the subretinal space. Inwardly rectifying K+ channels (Kir) on the apical membrane of retinal pigment epithelial (RPE) cells are thought to play an essential role in K+ transport in the subretinal space. 2. Single-channel recordings from the apical membrane of RPE cells exhibited functional expression of a Kir channel with properties identical to those of Kir4.1, while recordings from the basolateral membrane showed no detectable Kir channel currents. 3. The expression of Kir4.1 mRNA in RPE cells was confirmed by RT-PCR analysis and in situ hybridization. Furthermore, using immunohistochemistry, we found that Kir4.1 was prominently expressed in RPE cells and localized specifically on the processes on their apical membrane. 4. Developmental studies revealed that expression of Kir4.1 started to appear 10 days or later after birth in RPE cells, in parallel with the maturation of retinal neuronal activity as represented by the a- and b-waves of the electroretinogram. 5. These data suggest that Kir4.1 is one of the Kir channels involved in RPE-mediated control of K+ ions in the subretinal space.
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