ArticleProceedings of the National Academy of Sciences of the United States of America1999
Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Who cites it
39 citing papers in PubMed, 113 citations in OpenAlex.
- Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB.Journal of neurochemistry · 2023Article
- Effects of the Calcium Channel Blocker Otilonium Bromide on Seizure Activity in Rats With Pentylenetetrazole-Induced Convulsions.Neurochemical research · 2021Article
- Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial?Antioxidants (Basel, Switzerland) · 2020Review
- The nuclear receptor NR4A1 is regulated by SUMO modification to induce autophagic cell death.PloS one · 2020Article
- NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation.Journal of neuroinflammation · 2018Article
- Substance P Regulation in Epilepsy.Current neuropharmacology · 2018Review
- Article
- The role of substance P in epilepsy and seizure disorders.Oncotarget · 2017Review
- Protective Effects of Otophylloside N on Pentylenetetrazol-Induced Neuronal Injury In vitro and In vivo.Frontiers in pharmacology · 2016Article
- Neuropeptides as targets for the development of anticonvulsant drugs.Molecular neurobiology · 2014Review
- The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.Molecular and cellular neurosciences · 2014Article
- Intravenous administration of achyranthes bidentata polypeptides supports recovery from experimental ischemic stroke in vivo.PloS one · 2013Article
- Layer-specific CREB target gene induction in human neocortical epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Substance P causes seizures in neurocysticercosis.PLoS pathogens · 2012Article
- The nuclear receptor NR4A1 induces a form of cell death dependent on autophagy in mammalian cells.PloS one · 2012Article
- Myelin-associated glycoprotein protects neurons from excitotoxicity.Journal of neurochemistry · 2011Article
- The mammalian tachykinin ligand-receptor system: an emerging target for central neurological disorders.CNS & neurological disorders drug targets · 2010Review
- The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice.Journal of neurochemistry · 2009Article
- Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.The Journal of biological chemistry · 2009Article
- Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis.Journal of neuroscience research · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Epileptic seizures are associated with increases in hippocampal excitability, but the mechanisms that render the hippocampus hyperexcitable chronically (in epilepsy) or acutely (in status epilepticus) are poorly understood. Recent evidence suggests that substance P (SP), a peptide that has been implicated in cardiovascular function, inflammatory responses, and nociception, also contributes to hippocampal excitability and status epilepticus, in part by enhancing glutamate release. Here we report that mice with disruption of the preprotachykinin A gene, which encodes SP and neurokinin A, are resistant to kainate excitoxicity. The mice show a reduction in the duration and severity of seizures induced by kainate or pentylenetetrazole, and both necrosis and apoptosis of hippocampal neurons are prevented. Although kainate induced the expression of bax and caspase 3 in the hippocampus of wild-type mice, these critical intracellular mediators of cell death pathways were not altered by kainate injection in the mutant mice. These results indicate that the reduction of seizure activity and the neuroprotection observed in preprotachykinin A null mice are caused by the extinction of a SP/neurokinin A-mediated signaling pathway that is activated by seizures. They suggest that these neurokinins are critical to the control of hippocampal excitability, hippocampal seizures, and hippocampal vulnerability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.