ArticleProceedings of the National Academy of Sciences of the United States of America1999
Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 85 citations in OpenAlex.
- The Role of Scavenger Receptor BI in Sepsis.International journal of molecular sciences · 2024Review
- Alterations of HDL's to piHDL's Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies.Pharmaceuticals (Basel, Switzerland) · 2022Review
- FoxO transcription factors are required for hepatic HDL cholesterol clearance.The Journal of clinical investigation · 2018Article
- Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice.Journal of lipid research · 2015Article
- Expression, purification and reconstitution of the C-terminal transmembrane domain of scavenger receptor BI into detergent micelles for NMR analysis.Protein expression and purification · 2015Article
- Human scavenger receptor class B type I variants, lipid traits, and cardiovascular disease.Circulation. Cardiovascular genetics · 2014Article
- SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport.Biochemistry · 2014Article
- Hepatic scavenger receptor BI protects against polymicrobial-induced sepsis through promoting LPS clearance in mice.The Journal of biological chemistry · 2014Article
- Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- 2H2O-based high-density lipoprotein turnover method for the assessment of dynamic high-density lipoprotein function in mice.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks.Current opinion in endocrinology, diabetes, and obesity · 2013Review
- Role of scavenger receptors in glia-mediated neuroinflammatory response associated with Alzheimer's disease.Mediators of inflammation · 2013Review
- ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.Journal of lipid research · 2012Article
- Scavenger receptor class B member 1 protein: hepatic regulation and its effects on lipids, reverse cholesterol transport, and atherosclerosis.Hepatic medicine : evidence and research · 2011Review
- Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice.PloS one · 2010Article
- Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall.Journal of lipid research · 2009Article
- n-3 fatty acids reduce arterial LDL-cholesterol delivery and arterial lipoprotein lipase levels and lipase distribution.Arteriosclerosis, thrombosis, and vascular biology · 2009Article
- Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice.Molecular and cellular biochemistry · 2009Article
- Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors.Journal of lipid research · 2008Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Scavenger receptor BI (SR-BI) mediates the selective uptake of high density lipoprotein (HDL) cholesteryl esters (CE) by cells, i.e., the uptake of CE without degradation of HDL protein. Mice with attenuated expression of SR-BI, because of targeted gene mutation (SR-BIatt mice), have increased plasma HDL levels as a result of decreased selective uptake in the liver. To further evaluate the role of SR-BI in lipoprotein metabolism, compound apolipoprotein E knock-out (apoE0)/SR-BIatt mice were bred. Hepatic SR-BI protein was increased (2.3-fold) in apoE0 mice compared with wild type (wt) and was reduced significantly in apoE0/SR-BIatt mice. However, the plasma lipoprotein profile of apoE0 and apoE0/SR-BIatt mice was identical. This was explained by HDL turnover studies that revealed that the selective clearance of HDL CE by the liver and adrenal was already profoundly impaired in apoE0 mice compared with wt (28% of wt in liver). A similar decrease in selective uptake was seen when apoE0 HDL was incubated with isolated apoE0 hepatocytes. The results suggest that apoE plays a major role in the selective clearance of HDL CE by the liver and adrenal gland, possibly by facilitating the presentation of HDL to SR-BI at the cell surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.