ArticleProceedings of the National Academy of Sciences of the United States of America1999
Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 76 citations in OpenAlex.
- The role of plant metacaspases in cell death and survival.Cell death and differentiation · 2026Review
- Zn(2+) -induced Ca(2+) release via ryanodine receptors triggers calcineurin-dependent redistribution of cortical neuronal Kv2.1 K(+) channels.The Journal of physiology · 2016Article
- A novel SOD mimic with a redox-modulating mn (II) complex, ML1 attenuates high glucose-induced abnormalities in intracellular CaBiochemistry and biophysics reports · 2016Article
- Synergistic anticancer activities of the plant-derived sesquiterpene lactones salograviolide A and iso-seco-tanapartholide.Journal of natural medicines · 2013Article
- Calcineurin B subunit acts as a potential agent for preventing cardiac ischemia/reperfusion injury.Molecular and cellular biochemistry · 2012Article
- Diagnosis, pathogenesis, and treatment of autoimmune hepatitis after liver transplantation.Digestive diseases and sciences · 2012Review
- Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells.British journal of pharmacology · 2011Article
- Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing.Protein & cell · 2010Article
- Cyclosporine preserves mitochondrial morphology after myocardial ischemia/reperfusion independent of calcineurin inhibition.The Annals of thoracic surgery · 2008Article
- Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation.American journal of physiology. Heart and circulatory physiology · 2007Article
- High Bcl-2/Bax ratio in Walker tumor cells protects mitochondria but does not prevent H2O2-induced apoptosis via calcineurin pathways.Journal of bioenergetics and biomembranes · 2007Article
- Article
- Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.Molecular and cellular biology · 2006Article
- Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.Molecular biology of the cell · 2005Article
- Mechanisms of apoptosis in the heart.Journal of clinical immunology · 2003Review
- Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Article
- Lysosomal destabilization in p53-induced apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency.Molecular and cellular biology · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca(2+)-mobilizing compounds such as the Ca(2+) ionophore A23187 or the endoplasmic reticulum Ca(2+) ATPase inhibitor thapsigargin can suppress or induce apoptosis in the same cells. The use of different calcineurin inhibitors has shown that both suppression and induction of apoptosis by the Ca(2+)-mobilizing compounds were mediated by calcineurin activation. Ca(2+)-mobilizing compounds activated p38 and p44/42 mitogen-activated protein kinases (MAPKs). Induction of apoptosis by the Ca(2+)-mobilizing compounds was suppressed by an inhibitor of p38 MAPK but not by an inhibitor of p44/42 MAPK. These MAPK inhibitors did not suppress apoptosis induction by wild-type p53 or by withdrawal of IL-6 from IL-6-dependent cells that are mediated by calcineurin-independent pathways. These MAPK inhibitors also did not affect the ability of Ca(2+)-mobilizing compounds to suppress apoptosis. The results indicate that (i) Ca(2+)- mobilizing compounds activate different and opposing pathways that diverge downstream from calcineurin activation that can either suppress or induce apoptosis in the same cells; (ii) p38 MAPK but not p44/42 MAPK is involved in induction of apoptosis but not in its suppression by the Ca(2+)-mobilizing compounds; and (iii) neither p38 nor p44/42 MAPKs mediate induction of apoptosis by some calcineurin-independent pathways.
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