ArticleProceedings of the National Academy of Sciences of the United States of America1999
Interactions of G(h)/transglutaminase with phospholipase Cdelta1 and with GTP.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 91 citations in OpenAlex.
- Pathogenetic Contributions and Therapeutic Implications of Transglutaminase 2 in Neurodegenerative Diseases.International journal of molecular sciences · 2024Review
- Negative self-regulation of transient receptor potential canonical 4 by the specific interaction with phospholipase C-δ1.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- The Impact ofInternational journal of molecular sciences · 2023Article
- A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10.1 Voltage-Dependent KCancers · 2022Article
- LPCAT4 Knockdown Alters Barrier Integrity and Cellular Bioenergetics in Human Urothelium.International journal of molecular sciences · 2022Article
- Exploring the Role of Transglutaminase in Patients with Glioblastoma: Current Perspectives.OncoTargets and therapy · 2022Review
- Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Biological functionalities of transglutaminase 2 and the possibility of its compensation by other members of the transglutaminase family.TheScientificWorldJournal · 2014Review
- The Concise Guide to PHARMACOLOGY 2013/14: enzymes.British journal of pharmacology · 2013Article
- Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.The Journal of clinical investigation · 2013Article
- Structural basis for calcium and phosphatidylserine regulation of phospholipase C δ1.Biochemistry · 2012Article
- Genetic architecture of susceptibility to PCB126-induced developmental cardiotoxicity in zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response.The Journal of biological chemistry · 2011Article
- Transglutaminase-mediated remodeling of the human erythrocyte membrane skeleton: relevance for erythrocyte diseases with shortened cell lifespan.Advances in enzymology and related areas of molecular biology · 2011Review
- Type 2 transglutaminase in Huntington's disease: a double-edged sword with clinical potential.Journal of internal medicine · 2010Review
- Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.Chemistry & biology · 2008Article
- The Differential Effects of R580A Mutation on Transamidation and GTP Binding Activity of Rat and Human Type 2 Transglutaminase.International journal of clinical and experimental medicine · 2008Article
- Transglutaminase 2 undergoes a large conformational change upon activation.PLoS biology · 2007Article
- Identification of two GTP-independent alternatively spliced forms of tissue transglutaminase in human leukocytes, vascular smooth muscle, and endothelial cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2007Article
- Interactions of recombinant mouse erythrocyte transglutaminase with membrane skeletal proteins.The Journal of membrane biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The inositol phosphate hydrolyzing activity of human phospholipase Cdelta1 (PLCdelta1) is markedly inhibited when the enzyme is coexpressed with the human heart G(h)/transglutaminase (TG) in human embryonic kidney cells. Because the cotransfection does not affect the amount of PLCdelta1 in the cells, the depression of phospholipase activity probably is a result of a direct interaction between the two proteins. An ELISA procedure was employed to document the associations of purified TG preparations from a variety of tissues (human red cells, rabbit lens, guinea pig liver) with PLCdelta1. Nucleotides (GTP > GDP > ATP > GMP = ADP, in order of decreasing efficiency) interfered with the formation of the PLCdelta1:TG complex. A conformational change in the TG partner, occurring with nucleotide binding, is thought to be responsible for dissociating the two proteins. The structural rearrangement produces a remarkable shift in the anodic mobility of TG in electrophoresis: TG(slow) + GTP -->/<-- [TG:GTP](fast). Altogether, our findings indicate that GTP controls PLCdelta1 activity by releasing this protein from an inhibitory association with G(h)/transglutaminase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.