ArticleGut1999
The clinicopathological features of extensive small intestinal CD4 T cell infiltration.
Article in Gut, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Diagnostic clues in patients with clinical malabsorption and pathological small intestinal villous atrophy: Immune-mediated type and beyond.World journal of gastroenterology · 2026Review
- Immunological studies on the effects of toltrazuril and neem extract in broiler chickens suffering from coccidiosis.Open veterinary journal · 2024Article
- Few and far between: clinical management of rare extranodal subtypes of mature T-cell and NK-cell lymphomas.Haematologica · 2023Review
- Metronomic chemotherapy for indolent T-cell lymphoproliferative disorder of the gastrointestinal tract.Cancer science · 2023Article
- Indolent T-cell lymphoproliferative disorder of gastrointestinal tract with unusual clinical courses: report of 6 cases and literature review.Virchows Archiv : an international journal of pathology · 2023Review
- Extranodal T- and NK-cell lymphomas.Virchows Archiv : an international journal of pathology · 2023Review
- CD8-positive indolent T-Cell lymphoproliferative disorder of the gastrointestinal tract: A case report and review of literature.World journal of clinical cases · 2022Article
- Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders.Cancers · 2022Review
- Review
- Indolent T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract (iTLPD-GI): A Review.Cancers · 2021Review
- Intestinal NK/T cell lymphoma: A case report.World journal of gastroenterology · 2020Article
- Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract.Haematologica · 2020Article
- Indolent T cell lymphoproliferative disorder with villous atrophy in small intestine diagnosed by single-balloon enteroscopy.Clinical journal of gastroenterology · 2019Article
- Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report.Medicine · 2019Article
- Disease Progression in a Patient With Indolent T-Cell Lymphoproliferative Disease of the Gastrointestinal Tract.International journal of surgical pathology · 2019Article
- An unusual case report of indolent T-cell lymphoproliferative disorder with aberrant CD20 expression involving the gastrointestinal tract and bone marrow.Diagnostic pathology · 2018Article
- Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease.BMC veterinary research · 2018Review
- Indolent CD56-Positive Clonal T-Cell Lymphoproliferative Disease of the Stomach Mimicking Lymphomatoid Gastropathy.Korean journal of pathology · 2014Article
- Cytotoxic T-cell and NK-cell lymphomas: current questions and controversies.The American journal of surgical pathology · 2014Review
- Early lymphoid lesions: conceptual, diagnostic and clinical challenges.Haematologica · 2014Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
methodsFour patients with clinicopathological features suggesting a new distinct entity defining extensive small intestinal CD4 T cell infiltration were observed.
resultsAll four patients presented with chronic diarrhoea, malabsorption, and weight loss. Biopsy specimens of the small intestine disclosed extensive and diffuse infiltration of the lamina propria by pleomorphic small T lymphocytes, which were positive for CD3, CD4, CD5, and the beta chain of T cell receptor in all three cases studied and negative for CD103 in all three cases studied. It is notable that, in all invaded areas, the infiltrating cells showed no histological change throughout the whole evolution. In three patients, lymphocyte proliferation was monoclonal and there was extraintestinal involvement. In one patient, lymphoproliferation was oligoclonal and confined to the small intestine. In all four patients, there was no evidence of coeliac disease. Although none of the four patients responded to single or multiple drug chemotherapy, median survival was five years.
conclusionExtensive small intestinal CD4 T cell infiltration is a rare entity, distinct from coeliac disease and associated with prolonged survival.
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