ArticleThe Journal of physiology1999
Fast skeletal muscle troponin T increases the cooperativity of transgenic mouse cardiac muscle contraction.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Troponin: biology, molecular mechanisms, and multidimensional clinical applications.Molecular biomedicine · 2026Review
- Temperature dependence of activation of thick and thin filaments in skeletal and cardiac muscles.Journal of muscle research and cell motility · 2026Review
- Changes in Whey Proteome between Mediterranean and Murrah Buffalo Colostrum and Mature Milk Reflect Their Pharmaceutical and Medicinal Value.Molecules (Basel, Switzerland) · 2022Article
- Mechanisms of Frank-Starling law of the heart and stretch activation in striated muscles may have a common molecular origin.Journal of muscle research and cell motility · 2021Article
- Troponin Variants as Markers of Skeletal Muscle Health and Diseases.Frontiers in physiology · 2021Review
- Genomic and functional analysis of the host response to acute simian varicella infection in the lung.Scientific reports · 2016Article
- Abnormal splicing in the N-terminal variable region of cardiac troponin T impairs systolic function of the heart with preserved Frank-Starling compensation.Physiological reports · 2014Article
- Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I.FEBS open bio · 2013Article
- The N-terminal extension of cardiac troponin T stabilizes the blocked state of cardiac thin filament.Biophysical journal · 2012Article
- Chronic coexistence of two troponin T isoforms in adult transgenic mouse cardiomyocytes decreased contractile kinetics and caused dilatative remodeling.American journal of physiology. Cell physiology · 2012Article
- Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.Archives of biochemistry and biophysics · 2011Review
- Myofilament incorporation determines the stoichiometry of troponin I in transgenic expression and the rescue of a null mutation.Archives of biochemistry and biophysics · 2009Article
- Nonmyofilament-associated troponin T fragments induce apoptosis.American journal of physiology. Heart and circulatory physiology · 2009Article
- Differential regulation of myofilament protein isoforms underlying the contractility changes in skeletal muscle unloading.American journal of physiology. Cell physiology · 2007Article
- Troponin T core structure and the regulatory NH2-terminal variable region.Biochemistry · 2007Article
- Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage.Biochemistry · 2006Article
- Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility.American journal of physiology. Cell physiology · 2006Article
- Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
1. To investigate the functional significance of different troponin T (TnT) isoforms in the Ca2+ activation of muscle contraction, transgenic mice have been constructed with a chicken fast skeletal muscle TnT transgene driven by a cardiac alpha-myosin heavy chain gene promoter. 2. Cardiac muscle-specific expression of the fast skeletal muscle TnT has been obtained with significant myofibril incorporation. Expression of the endogenous cardiac muscle thin filament regulatory proteins, such as troponin I and tropomyosin, was not altered in the transgenic mouse heart, providing an authentic system for the functional characterization of TnT isoforms. 3. Cardiac muscle contractility was analysed for the force vs. Ca2+ relationship in skinned ventricular trabeculae of transgenic mice in comparison with wild-type litter-mates. The results showed unchanged pCa50 values (5.1 +/- 0.04 and 5.1 +/- 0.1, respectively) but significantly steeper slopes (the Hill coefficient was 2.0 +/- 0.2 vs. 1.0 +/- 0.2, P < 0.05). 4. The results demonstrate that the structural and functional variation of different TnT isoforms may contribute to the difference in responsiveness and overall cooperativity of the thin filament-based Ca2+ regulation between cardiac and skeletal muscles.
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Registered trials
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