ArticleThe Journal of physiology1999
The role of Ca2+ feedback in shaping InsP3-evoked Ca2+ signals in mouse pancreatic acinar cells.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal CaThe EMBO journal · 2020Article
- PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering CaAutophagy · 2019Article
- Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles.The Journal of cell biology · 2013Article
- Modeling of the modulation by buffers of Ca2+ release through clusters of IP3 receptors.Biophysical journal · 2009Article
- Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2+-binding proteins.The Journal of physiology · 2004Article
- Buffer kinetics shape the spatiotemporal patterns of IP3-evoked Ca2+ signals.The Journal of physiology · 2003Article
- Ca2+ signalling and membrane current activated by cADPr in starfish oocytes.Pflugers Archiv : European journal of physiology · 2003Article
- Modulation of IP(3)-sensitive Ca(2+) release by 2,3-butanedione monoxime.Pflugers Archiv : European journal of physiology · 2003Article
- Cytosolic Ca(2+) and Ca(2+)-activated Cl(-) current dynamics: insights from two functionally distinct mouse exocrine cells.The Journal of physiology · 2002Article
- Calcium wave propagation in pancreatic acinar cells: functional interaction of inositol 1,4,5-trisphosphate receptors, ryanodine receptors, and mitochondria.The Journal of general physiology · 2000Article
- Mechanisms underlying InsP3-evoked global Ca2+ signals in mouse pancreatic acinar cells.The Journal of physiology · 2000Article
- Phasic characteristic of elementary Ca(2+) release sites underlies quantal responses to IP(3).The EMBO journal · 2000Article
- A bimodal pattern of InsP(3)-evoked elementary Ca(2+) signals in pancreatic acinar cells.Biophysical journal · 2000Article
- Intercellular calcium waves in HeLa cells expressing GFP-labeled connexin 43, 32, or 26.Molecular biology of the cell · 2000Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
1. Cytosolic Ca2+ has been proposed to act as both a positive and a negative feedback signal on the inositol trisphosphate (InsP3) receptor. However, it is unclear how this might affect the Ca2+ response in vivo. 2. Mouse pancreatic acinar cells were whole-cell patch clamped to record the Ca2+-dependent chloride (Cl(Ca)) current spikes and imaged to record the cytosolic Ca2+ spikes elicited by the injection of Ins(2,4,5)P3. Increasing concentrations of Ca2+ buffer (up to 200 microM EGTA or BAPTA) were associated with the appearance of steps in the current activation phase and a prevalence of smaller-amplitude Cl(Ca) spikes. Imaging experiments showed that with increased buffer the secretory pole cytosolic Ca2+ signal became fragmented and spatially discrete Ca2+ release events were observed. 3. At higher buffer concentrations (200-500 microM), increasing concentrations of EGTA increased spike frequency and reduced spike amplitude. In contrast, BAPTA decreased spike frequency and maintained large spike amplitudes. 4. We conclude that, during InsP3-evoked spiking, long-range Ca2+ feedback ( approximately 2-4 microm) shapes the rising phase of the Ca2+ signal by acting to co-ordinate discrete Ca2+ release events and short-range ( approximately 40 nm) Ca2+ feedback acts to inhibit further Ca2+ release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.