ReviewThe Journal of physiology1999
Stimulation of exocytosis without a calcium signal.
Review in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 76 citations in OpenAlex.
- VIP and muscarinic synergistic mucin secretion by salivary mucous cells is mediated by enhanced PKC activity via VIP-induced release of an intracellular CaPflugers Archiv : European journal of physiology · 2020Article
- Phosphatidylinositol 4,5-bisphosphate drives CaThe Journal of biological chemistry · 2019Article
- L-Type Voltage-Gated CaCell reports · 2017Article
- Function Suggests Nano-Structure: Quantitative Structural Support for SNARE-Mediated Pore Formation.Neurotoxicity research · 2016Article
- Regulation of particulate matter-induced mucin secretion by transient receptor potential vanilloid 1 receptors.Inflammation · 2012Article
- Mechanisms and function of dendritic exocytosis.Neuron · 2011Review
- Cyclic AMP potentiates Ca2+-dependent exocytosis in pancreatic duct epithelial cells.The Journal of general physiology · 2010Article
- Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.Diabetologia · 2010Article
- Kinetics of PIP2 metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cells.The Journal of general physiology · 2010Article
- Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15.The Journal of experimental medicine · 2009Article
- Methods for detecting internalized, FM 1-43 stained particles in epithelial cells and monolayers.Biophysical journal · 2006Article
- Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size.The Journal of biological chemistry · 2006Article
- Multiple modes of GABAergic inhibition of rat cerebellar granule cells.The Journal of physiology · 2003Article
- Cyclic AMP is sufficient for triggering the exocytic recruitment of aquaporin-2 in renal epithelial cells.EMBO reports · 2003Article
- Sensitization of regulated exocytosis by protein kinase C.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Osmosensitive release of neurotransmitter amino acids: relevance and mechanisms.Neurochemical research · 2002Review
- Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Regulation of exocytosis by protein kinases and Ca(2+) in pancreatic duct epithelial cells.The Journal of general physiology · 2000Article
- Anterograde axonal transport, transcytosis, and recycling of neurotrophic factors: the concept of trophic currencies in neural networks.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
More than 30 years ago, Douglas (Douglas & Rubin, 1961; Douglas, 1968) proposed that intracellular Ca2+ controls stimulus-secretion coupling in endocrine cells, and Katz & Miledi (1967; Katz, 1969) proposed that intracellular Ca2+ ions control the rapid release of neurotransmitters from synapses. These related hypotheses have been amply confirmed in subsequent years and for students of excitable cells, they dominate our teaching and research. Calcium controls regulated exocytosis. On the other hand, many studies of epithelial and blood cell biology emphasize Ca2+-independent regulation of secretion of mucin, exocytotic delivery of transporters and degranulation. The evidence seems good. Are these contrasting conclusions somehow mistaken, or are the dominant factors controlling exocytosis actually different in different cell types? In this essay, we try to reconcile these ideas and consider classes of questions to ask and hypotheses to test in seeking a more integrated understanding of excitation-secretion coupling. Our review is conceptual and narrowly selective of a few examples rather than referring to a broader range of useful studies in the extensive literature. The examples are taken from mammals and are documented principally by citing other reviews and two of our own studies. The evidence shows that protein phosphorylation by kinases potentiates Ca2+-dependent exocytosis and often suffices to induce exocytosis by itself. Apparently, protein phosphorylation is the physiological trigger in a significant number of examples of regulated exocytosis. We conclude that although sharing many common properties, secretory processes in different cells are specialized and distinct from each other.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.