ArticleBritish journal of pharmacology1999
Acetylcholine-induced arteriolar dilation is reduced in streptozotocin-induced diabetic rats with motor nerve dysfunction.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Antihypertensive Effects of Diosmetin in Hypertension-Induced Cardiovascular Abnormalities in Rats.Journal of experimental pharmacology · 2025Article
- Combination therapy is it in the future for successfully treating peripheral diabetic neuropathy?Frontiers in endocrinology · 2024Review
- Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes.Journal of diabetes research · 2020Article
- Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications.International journal of molecular sciences · 2019Review
- Changes in IP3 Receptor Expression and Function in Aortic Smooth Muscle of Atherosclerotic Mice.Journal of vascular research · 2017Article
- Alternatives to the Streptozotocin-Diabetic Rodent.International review of neurobiology · 2016Review
- Characterization of diabetic neuropathy in the Zucker diabetic Sprague-Dawley rat: a new animal model for type 2 diabetes.Journal of diabetes research · 2014Article
- Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats.American journal of physiology. Endocrinology and metabolism · 2013Article
- Protective effect of Jiaweibugan decoction against diabetic peripheral neuropathy.Neural regeneration research · 2013Article
- Early loss of innervation of cornea epithelium in streptozotocin-induced type 1 diabetic rats: improvement with ilepatril treatment.Investigative ophthalmology & visual science · 2012Article
- Changes in corneal innervation and sensitivity and acetylcholine-mediated vascular relaxation of the posterior ciliary artery in a type 2 diabetic rat.Investigative ophthalmology & visual science · 2012Article
- Role of the effect of inhibition of neutral endopeptidase on vascular and neural complications in streptozotocin-induced diabetic rats.European journal of pharmacology · 2011Article
- Diet-induced obesity in Sprague-Dawley rats causes microvascular and neural dysfunction.Diabetes/metabolism research and reviews · 2010Article
- Treatment of Zucker diabetic fatty rats with AVE7688 improves vascular and neural dysfunction.Diabetes, obesity & metabolism · 2009Article
- The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy.Experimental diabetes research · 2009Article
- Vascular and neural dysfunctions in obese Zucker rats: effect of AVE7688.Experimental diabetes research · 2009Article
- NO- and non-NO-, non-prostanoid-dependent vasodilatation in rat sciatic nerve during maturation and developing experimental diabetic neuropathy.The Journal of physiology · 2002Article
- Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.The Journal of clinical investigation · 2001Article
- Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve.British journal of pharmacology · 2001Article
- Vascular Impairment of Epineurial Arterioles of the Sciatic Nerve: Implications for Diabetic Peripheral Neuropathy.The review of diabetic studies : RDSReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
1. Diabetes mellitus produces marked abnormalities in motor nerve conduction, but the mechanism is not clear. In the present study we hypothesized that in the streptozotocin (STZ)-induced diabetic rat impaired vasodilator function is associated with reduced endoneural blood flow (EBF) which may contribute to nerve dysfunction. 2. We examined whether diabetes-induced reductions in sciatic nerve conduction velocity and EBF were associated with impaired endothelium-dependent dilation in adjacent arterioles. We measured motor nerve conduction velocity (MNCV) in the sciatic nerve using a non-invasive procedure, and sciatic nerve nutritive blood flow using microelectrode polarography and hydrogen clearance. In vitro videomicroscopy was used to quantify arteriolar diameter responses to dilator agonists in arterioles overlying the sciatic nerve. 3. MNCV and EBF in 4-week-STZ-induced diabetic rats were decreased by 22% and 49% respectively. Arterioles were constricted with U46619 and dilation to acetylcholine (ACh), aprikalim, or sodium nitroprusside (SNP) examined. All agonists elicited dose-dependent dilation in control and diabetic rats, although ACh-induced dilation was significantly reduced in diabetic rats. Treating vessels from normal or diabetic rats with indomethacin (INDO) alone did not significantly affect ACh-induced relaxation. However, ACh-induced vasodilation was significantly reduced by treatment with KCl or Nomega-nitro-L-arginine (LNNA) alone. Combining LNNA and KCl further reduced ACh-induced dilation in these vessels. 4. Diabetes causes vasodilator dysfunction in a microvascular bed that provides circulation to the sciatic nerve. These studies imply that ACh-induced dilation in these vessels is mediated by multiple mechanisms that may include the endothelial-dependent production of nitric oxide and endothelial-derived hyperpolarizing factor. This impaired vascular response is associated with neural dysfunction.
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