ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 136 citations in OpenAlex.
- BDNF Signaling and Pain Modulation.Cells · 2025Review
- Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.The Journal of cell biology · 2023Article
- Understanding the development of oral epithelial organs through single cell transcriptomic analysis.Development (Cambridge, England) · 2022Article
- TGFβ-Neurotrophin Interactions in Heart, Retina, and Brain.Biomolecules · 2021Review
- Identification of key miRNAs and genes for mouse retinal development using a linear model.Molecular medicine reports · 2020Article
- Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage.Investigative ophthalmology & visual science · 2018Article
- Neuroprotective effects of quercetin in diabetic rat retina.Saudi journal of biological sciences · 2017Article
- Functional ectopic neuritogenesis by retinal rod bipolar cells is regulated by miR-125b-5p during retinal remodeling in RCS rats.Scientific reports · 2017Article
- Role of BDNF/TrkB pathway in the visual system: Therapeutic implications for glaucoma.Expert review of ophthalmology · 2017Article
- Serum Levels of Brain-Derived Neurotrophic Factor Are Associated with Diabetes Risk, Complications, and Obesity: a Cohort Study from Chinese Patients with Type 2 Diabetes.Molecular neurobiology · 2016Article
- Conjunctivally Applied BDNF Protects Photoreceptors from Light-Induced Damage.Translational vision science & technology · 2015Article
- Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia.Investigative ophthalmology & visual science · 2015Article
- Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness.International journal of nanomedicine · 2015Review
- Downregulation of microRNA-100 protects apoptosis and promotes neuronal growth in retinal ganglion cells.BMC molecular biology · 2014Article
- Aerobic exercise protects retinal function and structure from light-induced retinal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- N-acetylserotonin: circadian activation of the BDNF receptor and neuroprotection in the retina and brain.Advances in experimental medicine and biology · 2014Article
- Mice with altered BDNF signaling as models for mood disorders and antidepressant effects.Frontiers in behavioral neuroscience · 2014Review
- Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation.Molecular and cellular biology · 2013Article
- Reduced levels of brain derived neurotrophic factor (BDNF) in the serum of diabetic retinopathy patients and in the retina of diabetic rats.Cellular and molecular neurobiology · 2013Article
- EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons.Nature neuroscience · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) acts through TrkB, a receptor with kinase activity, and mitigates light-induced apoptosis in adult mouse rod photoreceptors. To determine whether TrkB signaling is necessary for rod development and function, we examined the retinas of mice lacking all isoforms of the TrkB receptor. Rod migration and differentiation occur in the mutant retina, but proceed at slower rates than in wild-type mice. In postnatal day 16 (P16) mutants, rod outer segment dimensions and rhodopsin content are comparable with those of photoreceptors in P12 wild type (WT). Quantitative analyses of the photoreceptor component in the electroretinogram (ERG) indicate that the gain and kinetics of the rod phototransduction signal in dark-adapted P16 mutant and P12 WT retinas are similar. In contrast to P12 WT, however, the ERG in mutant mice entirely lacks a b-wave, indicating a failure of signal transmission in the retinal rod pathway. In the inner retina of mutant mice, although cells appear anatomically and immunohistochemically normal, they fail to respond to prolonged stroboscopic illumination with the normal expression of c-fos. Absence of the b-wave and failure of c-fos expression, in view of anatomically normal inner retinal cells, suggest that lack of TrkB signaling causes a defect in synaptic signaling between rods and inner retinal cells. Retinal pigment epithelial cells and cells in the inner retina, including Müller, amacrine, and retinal ganglion cells, express the TrkB receptor, but rod photoreceptors do not. Moreover, inner retinal cells respond to exogenous BDNF with c-fos expression and extracellular signal-regulated kinase phosphorylation. Thus, interactions of rods with TrkB-expressing cells must be required for normal rod development.
Indexed as
Identifiers
10516311PMC2757409W2116050939What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.