ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Modulation of the light response by cAMP in Drosophila photoreceptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
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- Aging and Light Stress Result in Overlapping and Unique Gene Expression Changes in Photoreceptors.Genes · 2022Article
- Opposing Actions of Octopamine and Tyramine on Honeybee Vision.Biomolecules · 2021Article
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- Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration.The Journal of clinical investigation · 2020Article
- Neuromodulation of insect motion vision.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Vitamin BCell research · 2019Article
- Modulation of voltage-dependent K+ conductances in photoreceptors trades off investment in contrast gain for bandwidth.PLoS computational biology · 2018Article
- Abnormal visual gain control and excitotoxicity in early-onset Parkinson's disease Drosophila models.Journal of neurophysiology · 2018Article
- Classification of Parkinson's Disease Genotypes in Drosophila Using Spatiotemporal Profiling of Vision.Scientific reports · 2015Article
- Neurophysiology of Drosophila models of Parkinson's disease.Parkinson's disease · 2015Review
- Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway.The Journal of physiology · 2014Article
- Abnormal visual gain control in a Parkinson's disease model.Human molecular genetics · 2014Article
- Differences in the phototaxis of pollen and nectar foraging honey bees are related to their octopamine brain titers.Frontiers in physiology · 2014Article
- Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy.Human molecular genetics · 2013Article
- Dopaminergic modulation of ganglion-cell photoreceptors in rat.The European journal of neuroscience · 2012Article
- Roles of dopamine in circadian rhythmicity and extreme light sensitivity of circadian entrainment.Current biology : CB · 2010Article
- The dopaminergic system in the aging brain of Drosophila.Frontiers in neuroscience · 2010Article
- Octopaminergic modulation of temporal frequency coding in an identified optic flow-processing interneuron.Frontiers in systems neuroscience · 2010Article
- Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.Experimental eye research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phototransduction in Drosophila is mediated by a G-protein-coupled phospholipase C transduction cascade in which each absorbed photon generates a discrete electrical event, the quantum bump. In whole-cell voltage-clamp recordings, cAMP, as well as its nonhydrolyzable and membrane-permeant analogs 8-bromo-cAMP (8-Br-cAMP) and dibutyryl-cAMP, slowed down the macroscopic light response by increasing quantum bump latency, without changes in bump amplitude or duration. In contrast, cGMP or 8-Br-cGMP had no effect on light response amplitude or kinetics. None of the cyclic nucleotides activated any channels in the plasma membrane. The effects of cAMP were mimicked by application of the non-specific phosphodiesterase inhibitor IBMX and the adenylyl cyclase activator forskolin; zaprinast, a specific cGMP-phosphodiesterase inhibitor, was ineffective. Bump latency was also increased by targeted expression of either an activated G(s) alpha subunit, which increased endogenous adenylyl cyclase activity, or an activated catalytic protein kinase A (PKA) subunit. The action of IBMX was blocked by pretreatment with the PKA inhibitor H-89. The effects of cAMP were abolished in mutants of the ninaC gene, suggesting this nonconventional myosin as a possible target for PKA-mediated phosphorylation. Dopamine (10 microM) and octopamine (100 microM) mimicked the effects of cAMP. These results indicate the existence of a G-protein-coupled adenylyl cyclase pathway in Drosophila photoreceptors, which modulates the phospholipase C-based phototransduction cascade.
Indexed as
Identifiers
10516299PMC6782748W2111867236What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.