ArticleJournal of virology1999
The trophoblastic epithelial barrier is not infected in full-term placentae of human immunodeficiency virus-seropositive mothers undergoing antiretroviral therapy.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- A preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia.Malaria journal · 2006Trial
- Placenta models for HIV-1-ART-nicotine comorbidity research: advances and remaining challenges.Cell death discovery · 2026Review
- The Role and Function of Regulatory T Cells inJournal of immunology research · 2021Review
- Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action.Cell reports · 2017Article
- HLA-G 14 bp deletion/insertion polymorphism and mother-to-child transmission of HIV.Tissue antigens · 2014Article
- Role of the placenta in adverse perinatal outcomes among HIV-1 seropositive women.Journal of Nippon Medical School = Nippon Ika Daigaku zasshi · 2013Review
- Histomorphometric and immunohistochemical analysis of infectious agents, T-cell subpopulations and inflammatory adhesion molecules in placentas from HIV-seropositive pregnant women.Diagnostic pathology · 2011Article
- HIV-1 co-receptor usage: influence on mother-to-child transmission and pediatric infection.Journal of translational medicine · 2011Review
- Human Immunodeficiency Virus type 1 in seronegative infants born to HIV-1-infected mothers.Virology journal · 2006Article
- Review
- Options for prevention of HIV transmission from mother to child, with a focus on developing countries.Paediatric drugs · 2002Review
- Placental cytokine and chemokine production in HIV-1-infected women: trophoblast cells show a different pattern compared to cells from HIV-negative women.Clinical and experimental immunology · 2001Article
- Cell-to-cell contact results in a selective translocation of maternal human immunodeficiency virus type 1 quasispecies across a trophoblastic barrier by both transcytosis and infection.Journal of virology · 2001Article
- Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women.The Journal of clinical investigation · 2001Article
- Production of interferons and beta-chemokines by placental trophoblasts of HIV-1-infected women.Infectious diseases in obstetrics and gynecology · 2001Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the mechanism of the placental barrier function, we examined 10 matched samples of term placentae, cord blood, and maternal blood obtained at delivery from human immunodeficiency virus (HIV)-infected mothers with children diagnosed as HIV negative in Sweden. All placentae were histologically normal, and immunochemistry for HIV type 1 p24 and gp120 antigens was negative. Highly purified trophoblasts (93 to 99% purity) were negative for HIV DNA and RNA, indicating that the trophoblasts were uninfected. Although HIV DNA was detected in placenta-derived T lymphocytes and monocytes, microsatellite analysis showed that these cells were a mixture of maternal and fetal cells. Our study indicates that the placental barrier, i.e., the trophoblastic layer, is not HIV infected and, consequently, HIV infection of the fetus is likely to occur through other routes, such as breaks in the placental barrier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.