ArticleJournal of bacteriology1999
Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae.
Article in Journal of bacteriology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 79 citations in OpenAlex.
- The effect of MurM and a branched cell wall structure on penicillin resistance inJournal of bacteriology · 2025Article
- Dual CRISPRi-seq for genome-wide genetic interaction studies identifies key genes involved in the pneumococcal cell cycle.Cell systems · 2025Article
- Review
- Genomic Traits Associated with Virulence and Antimicrobial Resistance of Invasive Group B Streptococcus Isolates with Reduced Penicillin Susceptibility from Elderly Adults.Microbiology spectrum · 2022Article
- A Tn-seq Screen of Streptococcus pneumoniae Uncovers DNA Repair as the Major Pathway for Desiccation Tolerance and Transmission.Infection and immunity · 2021Article
- Defining the regulon of genes controlled by σMolecular microbiology · 2019Article
- Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis.Nature communications · 2019Article
- Phosphorylation-dependent activation of the cell wall synthase PBP2a inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Suppression and synthetic-lethal genetic relationships of ΔgpsB mutations indicate that GpsB mediates protein phosphorylation and penicillin-binding protein interactions in Streptococcus pneumoniae D39.Molecular microbiology · 2017Article
- Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously.Nature microbiology · 2016Article
- Promoter Identification and Transcription Analysis of Penicillin-Binding Protein Genes in Streptococcus pneumoniae R6.Microbial drug resistance (Larchmont, N.Y.) · 2016Article
- Suppression of a deletion mutation in the gene encoding essential PBP2b reveals a new lytic transglycosylase involved in peripheral peptidoglycan synthesis in Streptococcus pneumoniae D39.Molecular microbiology · 2016Article
- Mechanism of β-lactam action in Streptococcus pneumoniae: the piperacillin paradox.Antimicrobial agents and chemotherapy · 2015Article
- Penicillin-binding protein 2x of Streptococcus pneumoniae: the mutation Ala707Asp within the C-terminal PASTA2 domain leads to destabilization.Microbial drug resistance (Larchmont, N.Y.) · 2014Article
- Interplay of the serine/threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division.PLoS genetics · 2014Article
- Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39.Molecular microbiology · 2013Article
- The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a.Journal of bacteriology · 2011Article
- Monofunctional transglycosylases are not essential for Staphylococcus aureus cell wall synthesis.Journal of bacteriology · 2011Article
- Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity.Natural product reports · 2010Review
- The genome of Streptococcus mitis B6--what is a commensal?PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of inactivation of the genes encoding penicillin-binding protein 1a (PBP1a), PBP1b, and PBP2a in Streptococcus pneumoniae were examined. Insertional mutants did not exhibit detectable changes in growth rate or morphology, although a pbp1a pbp1b double-disruption mutant grew more slowly than its parent did. Attempts to generate a pbp1a pbp2a double-disruption mutant failed. The pbp2a mutants, but not the other mutants, were more sensitive to moenomycin, a transglycosylase inhibitor. These observations suggest that individually the pbp1a, pbp1b, and pbp2a genes are dispensable but that either pbp1a or pbp2a is required for growth in vitro. These results also suggest that PBP2a is a functional transglycosylase in S. pneumoniae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.