ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology1999
The DAPI banded karyotype of the domestic dog (Canis familiaris) generated using chromosome-specific paint probes.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 114 citations in OpenAlex.
- From cytogenetics to cytogenomics: a new era in the diagnosis of chromosomal abnormalities in domestic animals.Journal of applied genetics · 2025Review
- Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study.Vaccine · 2024Article
- Is increased mutation driving genetic diversity in dogs within the Chornobyl exclusion zone?PloS one · 2024Article
- Hi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution.Molecular ecology resources · 2021Article
- Clinical Cytogenetics of the Dog: A Review.Animals : an open access journal from MDPI · 2021Review
- Structural and copy number chromosome abnormalities in canine cutaneous mast cell tumours.Journal of applied genetics · 2019Article
- Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy.Journal of cellular and molecular medicine · 2017Article
- Speciation network in Laurasiatheria: retrophylogenomic signals.Genome research · 2017Article
- Fluorescence chromosome banding and FISH mapping in perennial ryegrass, Lolium perenne L.BMC genomics · 2016Article
- A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- Canine prostate cancer cell line (Probasco) produces osteoblastic metastases in vivo.The Prostate · 2014Article
- Chromosomal rearrangements and karyotype evolution in carnivores revealed by chromosome painting.Heredity · 2012Article
- Article
- Development of a brain metastatic canine prostate cancer cell line.The Prostate · 2011Article
- Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
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- 'Putting our heads together': insights into genomic conservation between human and canine intracranial tumors.Journal of neuro-oncology · 2009Article
- Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Genomic characterisation, chromosomal assignment and in vivo localisation of the canine high mobility group A1 (HMGA1) gene.BMC genetics · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The domestic dog (Canis familiaris) is widely used as a model in the study of human disease. However, many of the 78 chromosomes comprising the canine karyotype are extremely difficult to identify reliably by classical cytogenetics. This has been a major hindrance to molecular cytogenetic studies of this species. The Animal Health Trust and the Sanger Centre have developed a set of canine whole chromosome-specific fluorescence in situ hybridisation (FISH) probes (chromosome paints). We have used these chromosome paints to identify unequivocally each chromosome in a metaphase spread. An increasing number of laboratories are making use of cooled CCD cameras and sophisticated software for FISH mapping. Consequently, there is a major trend towards the use of DAPI banding for concurrent chromosome identification during FISH analyses in a range of species. Here we present, for the first time, a complete DAPI banded karyotype of the dog in which each chromosome has been accurately placed, together with a 460-band DAPI ideogram. These data will facilitate the accurate assignment of FISH-mapped loci to all chromosomes comprising the karyotype and form the basis for an agreed standard of the dog karyotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.