ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology1999
Identification of the gene-richest bands in human prometaphase chromosomes.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 119 citations in OpenAlex.
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- Morphometric Analysis of Recognized Genes for Autism Spectrum Disorders and Obesity in Relationship to the Distribution of Protein-Coding Genes on Human Chromosomes.International journal of molecular sciences · 2016Article
- Cell line differences in replication timing of human glutamate receptor genes and other large genes associated with neural disease.Epigenetics · 2014Article
- Implications of human genome structural heterogeneity: functionally related genes tend to reside in organizationally similar genomic regions.BMC genomics · 2014Article
- Tyrosine hydroxylase gene: another piece of the genetic puzzle of Parkinson's disease.CNS & neurological disorders drug targets · 2012Review
- The footprint of metabolism in the organization of mammalian genomes.BMC genomics · 2012Article
- Replication timing, chromosomal bands, and isochores.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Human chromosomal bands: nested structure, high-definition map and molecular basis.Chromosoma · 2007Article
- Comparative isoschizomer profiling of cytosine methylation: the HELP assay.Genome research · 2006Article
- Avian genomes: different karyotypes but a similar distribution of the GC-richest chromosome regions at interphase.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Article
- DNA helix: the importance of being GC-rich.Nucleic acids research · 2003Article
- Informatics for unveiling hidden genome signatures.Genome research · 2003Article
- Genes on human chromosome 19 show extreme divergence from the mouse orthologs and a high GC content.Nucleic acids research · 2002Article
- Compositional mapping of chicken chromosomes and identification of the gene-richest regions.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2001Article
- Genes, isochores and bands in human chromosomes 21 and 22.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2001Article
- Assessment of compositional heterogeneity within and between eukaryotic genomes.Genome research · 2000Article
- An isochore transition in the NF1 gene region coincides with a switch in the extent of linkage disequilibrium.American journal of human genetics · 2000Article
- Gene density in the Giemsa bands of human chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human genome is a mosaic of long, compositionally homogeneous DNA segments, the isochores, that can be partitioned into five families, two GC-poor families (L1 and L2), representing 63% of the genome, and three GC-rich families (H1, H2 and H3), representing 24%, 7.5% and 4-5% of the genome, respectively. Gene concentration increases with increasing GC levels, reaching a level 20-fold higher in H3 compared with L isochores. In-situ hybridization of DNA from different isochore families provides, therefore, information on the chromosomal distribution of genes. Using this approach, three subsets of reverse or Giemsa-negative bands, H3+, H3* and H3-, containing large, moderate, and no detectable amounts, respectively, of the gene-richest H3 isochores were identified at a resolution of 400 bands. H3+ bands largely coincide with the most heat-denaturation-resistant bands, the chromomycin-A3-positive, DAPI-negative bands, the bands with the highest CpG island concentrations, and the earliest replicating bands. Here, we have defined the H3+ bands at a 850-band resolution, and have thus identified the human genome regions, having an average size of 4 Mb, that are endowed with the highest gene density.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.