ArticleThe American journal of pathology1999
The PEN5 epitope identifies an oligodendrocyte precursor cell population and pilocytic astrocytomas.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- MAPK pathway activation in pilocytic astrocytoma.Cellular and molecular life sciences : CMLS · 2012Review
- Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival.Journal of neuro-oncology · 2008Article
- Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas.Journal of neuro-oncology · 2006Article
- Molecular pathogenesis of childhood brain tumors.Journal of neuro-oncology · 2004Review
- Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas.The American journal of pathology · 2004Article
- CD44H is expressed by cells of the oligodendrocyte lineage and by oligodendrogliomas in humans.Journal of neuro-oncology · 2002Article
- Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.Molecular and cellular biology · 2002Article
- Mouse models of neurofibromatosis 1 and 2.Neoplasia (New York, N.Y.)Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PEN5 is a sulfated polylactosamine carbohydrate epitope first described in a subpopulation of mature natural killer cells. Here we report that it is also expressed in a developmentally regulated fashion in human and rat central nervous systems and that its protein carrier is P-selectin glycoprotein ligand-1 (PSGL-1), a ligand for selectins. In rat neural primary cultures, PEN5 is transiently and selectively expressed by oligodendrocyte precursor cells and marks the transition from proliferative to postmitotic stages. In concordance, in human central nervous system tumors, PEN5 is observed in a subset of oligodendrogliomas and in all pilocytic astrocytomas, a class of tumor of uncertain histogenesis. These data suggest that PEN5-PSGL-1 plays a role in the differentiation of oligodendrocytes and that pilocytic astrocytomas are likely to result from a dysregulation occurring in oligodendrocyte precursor cells at the crucial stage of exit from the cell cycle.
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